Sunday, July 12, 2015

WBUT B.Sc Microbiology MEDICAL MOLECULAR BIOLOGY Question Paper 2012

University:West Bengal University of Technology
Course: B.Sc
Subject :  MEDICAL MOLECULAR BIOLOGY

Year of  Question Paper : 2012





CS/B.Sc.(H)MOLBIO/SEM-6/MMB-602/2012

2012

MEDICAL MOLECULAR BIOLOGY

Time Allotted : 3 Hours Full Marks : 70

The figures in the margin indicate full marks.

Candidates are required to give their answers in their own words as

far as practicable.

GROUP – A

( Multiple Choice Type Questions )

1. Choose the correct alternatives for any ten of the following :

10 × 1 = 10

i) Which year National Institute of Health took lead in

recombinant DNA ( rDNA ) research regulation ?

a) 1970 b) 1974

c) 1980 d) 1985.

ii) In which year did Dr. Martin Cline perform first DNA

transfer into bone marrow cells ?

a) 1975 b) 1980

c) 1982 d) 1987.

iii) In which year US Office of Technology Assessment

stressed the difference between somatic and germ-line

therapy ?

a) 1982 b) 1984

c) 1987 d) 1989.

iv) In which year did NIM perform the first approved gene

therapy procedure ?

a) 1985 b) 1990c) 1997 d) 2003.

v) Some cells of blastocyst ( 5 to 14 days ) are known as

a) Totipotent b) Pluripotent

c) Multipotent d) None of these.

vi) Cells differentiated, but can form a number of other

tissues are known as

a) Pluripotent b) Multipotent

c) Totipotent d) None of these.

vii) Which novel therapeutic molecule treats human

disease ?

a) miRNAs b) antisenseRNAs

c) shRNAs d) siRNAs.

viii) Genetic Locus Repetitive Behaviours of Autism are

discovered on chromosome

a) 10 b) 15

c) 18 d) 22.

ix) The proteins encoded by proto-oncogenes participated

in various metabolic processes including

a) Regulation of transcription

b) Cell-to-cell signalling

c) Intracellular signalling transduction

d) All of these.

x) CDK4/6-Cyclin D is the CDK-Cyclin complex of

a) G1 Phase of cell cycle b) G2 Phase of cell cycle

c) S Phase of cell cycle d) M Phase of cell cycle.

xi) Jun and Fos oncogenes are

a) G proteins b) Protein kinases

c) Transcription factors d) Cell receptors.

xii) Retinoblastoma is a tumor suppressor protein
and is

directly involved in

a) Transmission of extracellular signals to the nucleus

b) Cell cycle progression

c) Cytoskeletal rearrangement

d) General inhibition of various oncoproteins.

GROUP – B

( Short Answer Type Questions )

Answer any three of the following. 3 × 5 = 15

2. Define the role of Oncogenes in cancer.

3. Explain the role of polymer vectors in Gene Therapy.

4. Describe the role of Dopamine pathways in Human Brain

System.

5. Why is adult stem cell therapy getting preference over other

approaches of Gene therapy ?

6. What is therapeutic cloning ? How is it used in clinical

practice ?

GROUP – C

( Long Answer Type Questions )

Answer any three of the following. 3 × 15 = 45

7. Define Genetic causes of Breast Cancer. What is the

inheritance pattern of Breast Cancer ? What is the Molecular

Diagnostic Test ? What would be Genetic counselling to an

affected family ? 3 + 3 + 5 + 4

8. What are non-viral vectors in Gene Therapy ? Describe

various approaches of non-viral vectors delivery. What are

the major barriers of DNA delivery ? 3 + 6 + 6

9. Describe the critical period of Human Brain development.What are the factors essential for

development of Brain ?

6 + 9

10. What is Autism ? What are the typical features observed in

autistic behaviour ? Describe the evidences of genetic

factors involved. 3 + 5 + 7

11. Describe the mechanism leading to loss of Hetrozygosity in

Cancer. Write few names of dominantly inherited cancer

syndromes and recessive inherited cancer syndrome. 8 + 7

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