FIRST M.B.B.S.,2014 Question Paper, Dr. MGR University Question Paper,Paper V – BIOCHEMISTRY – I

Dr. MGR University Question Paper
FIRST M.B.B.S. DEGREE EXAMINATION
Paper V – BIOCHEMISTRY – I
Q. P. Code : 524055
Time: Three Hours Maximum: 50 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Elaborate on: (1 x 10 = 10)
 1. Describe in detail about the metabolic change and complications in Diabetes Mellitus.
 Add a short note on the biochemical investigations to be done in Diabetes Mellitus.
II. Write Notes on: (2 x 5 = 10)
 1. Write in detail about compounds which affects Electron Transport Chain & Oxidative
 Phosphorylation.
 2. Write about the biological actions & clinical applications of Prostaglandins.
III. Short Answers on: (10 x 3 = 30)
 1. Therapeutic uses of Enzymes.
2. Types of Lipases.
3. Lipotrophic Factors.
4. Metabolism of Propionyl CoA.
5. Prevention of Atherosclerosis.
6. Allosteric regulation.
7. Significance of multi-enzyme complexes with example.
8. Vitamin -D deficiency.
9. Functions of Phosphate.
 10. What is Saponification and Iodine Number? Write its importance.
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Dr. MGR University Question Paper,Paper V – BIOCHEMISTRY – I,2014 Question Paper,FIRST M.B.B.S.

Dr. MGR University Question Paper
FIRST M.B.B.S. DEGREE EXAMINATION
Paper V – BIOCHEMISTRY – I
Q. P. Code : 524055
Time: Three Hours Maximum: 50 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Elaborate on: (1 x 10 = 10)
 1. Describe the beta oxidation of Palmitic acid and its regulation.
II. Write Notes on: (2 x 5 = 10)
 1. Coenzymic role of Pyridoxine.
 2. Factors regulating blood calcium.
III. Short Answers on: (10 x 3 = 30)
 1. Wilson’s disease.
2. Define isoenzymes and give two examples.
3. Specific dynamic action.
4. Chemiosmotic theory.
5. Von Gierke’s disease.
6. Pyruvate dehydrogenase complex.
7. Ionophores.
8. Oral glucose tolerance test.
9. Deficiency manifestations of vitamin D.
 10. Biochemical functions of Iron.
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2014 Question Paper,FIRST M.B.B.S.,Paper V – BIOCHEMISTRY – I,Dr. MGR University Question Paper

Dr. MGR University Question Paper
FIRST M.B.B.S. DEGREE EXAMINATION
Paper V – BIOCHEMISTRY – I
Q. P. Code : 524055
Time : 180 Minutes Maximum: 50 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Elaborate on: (2 x 7.5 = 15)
 1. Describe the synthesis of glucose from alanine and mention its regulation.
 2. How are low-density lipoproteins (LDL) produced in the body?
 Describe, with the help of a diagram, their metabolic fate.
 What determines this process of their metabolic fate?
 Explain the clinical significance of this lipoprotein.
II. Write notes on: (10 x 2.5 = 25)
1. Name 5 enzymes, serum levels of which are increased in disease conditions, along with the
corresponding disease condition where such changes are seen.
2. Briefly explain the chemiosmotic hypothesis of Mitchell.
3. What is meant by dietary fibre? Explain its importance in one’s diet.
4. Explain the folate trap hypothesis.
5. What is surfactant? Explain its importance in the body in health and disease.
6. Explain, with a diagram, the fluid mosaic model of cell membranes.
7. What are good dietary sources of iron?
 Explain how iron is absorbed from the gastrointestinal tract.
8. Explain how the activity of an enzyme is affected by the pH of the medium.
9. What are the functions of calcium in the body?
 10. Describe the functions and deficiency manifestations of vitamin A.
III. Short Answers on: (10 x 1 = 10)
1. Explain the mechanism of action of cyanide as a poison.
2. List 2 differences between hexokinase and glucokinase.
3. Give 2 examples of drugs that act as inhibitors of enzyme and name the enzyme that each
one inhibits.
4. Explain the role of 2, 3 bisphosphoglycerate in supply of oxygen to tissue.
5. List 2 differences between foetal and adult forms of haemoglobin.
6. Why do patients with cholelithiasis often pass clay-coloured stools?
7. What is meant by the metabolic syndrome? What is the significance of this condition?
8. Write two functions & RDA of pyridoxine.
9. List 2 differences between marasmus and kwashiorkor?
 10. Give two examples of substrate level phosphorylation.
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Paper V – BIOCHEMISTRY – I,FIRST M.B.B.S.,2013 Question Paper,Dr. MGR University Question Paper

Dr. MGR University Question Paper
FIRST M.B.B.S. DEGREE EXAMINATION
Paper V – BIOCHEMISTRY – I
Q. P. Code : 524055
Time : 180 Minutes Maximum: 50 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Elaborate on: (2 x 7.5 = 15)
 1. Classify enzymes. Describe in detail the various factors affecting enzyme action.
 Add a note on enzyme regulation
 2. Name the ketone bodies? How are they formed and utilised in the body.
 Add a note on the metabolic changes in diabetic ketoacidosis.
II. Write notes on: (10 x 2.5 = 25)
1. 2,3 BPG- Formation & its role.
2. Mechanism of synthesis of ATP in ETC
3. Explain ‘Methyl Folate trap’
4. Carnitine shuttle
5. What are dietary fibres and explain their importance in human nutrition with
 respect to the prevention of diseases
6. Write briefly about the significance of HMP shunt pathway
7. Sources, RDA & Biological role of Vitamin C
8. Describe the energetics of complete oxidation of 1 mole of glucose to CO2 & H2O
 under aerobic conditions
9. Bile salts – Synthesis & biological role.
 10. Write briefly about calcium homeostasis.
III. Short Answers on: (10 x 1 = 10)
1. What are zymogens. Give an example
2. Mention two inhibitors of ETC with their site of action
3. What is specific dynamic action and importance in calculating caloric
 requirements of an individual.
4. What are trace mineral. Give RDA of any 2 of them.
5. What is Steatorrhoea ?
6. What is Suicide inhibition? Give an example
7. Laboratory Criteria for diagnosis of Diabetes Mellitus.
8. Name the insulin dependent glucose transporters and their tissue distribution.
9. What is pulmonary surfactant and its clinical importance?
 10. What is the biochemical basis of development of cataract in Diabetes Mellitus.
******* 

FIRST M.B.B.S.,2013 Question Paper,Paper V – BIOCHEMISTRY – I,Dr. MGR University Question Paper

Dr. MGR University Question Paper
FIRST M.B.B.S. DEGREE EXAMINATION
Paper V – BIOCHEMISTRY – I
Q. P. Code : 524055
Time : 180 Minutes Maximum: 50 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Elaborate on: (2 x 7.5 = 15)
 1. What is the normal blood sugar level?
 Describe in detail how it is maintained within normal limits.
 2. Mention the source, daily requirement of vitamin B12.
 Describe its absorption biochemical function and deficiency manifestations.
II. Write notes on : (10 x 2.5 = 25)
1. Fatty liver & lipotropic factors
2. Digestion and absorption, transport of iron
3. Isoenzymes and their diagnostic importance
4. Define Biological Oxidation & mechanism of ATP synthesis
5. The principles of balances diet
6. Transport mechanism-across cell membrane
7. Cytochrome P450
8. Galactosemia
9. Prostaglandins and their importance
 10. Ketosis
III. Short Answers on: (10 x 1 = 10)
1. Key enzyme of cholesterol synthesis and its regulation
2. FIGLU
3. Refsum’s disease
4. Comparison between prokaryotic an eukaryotic cells
5. Glycosides
6. Metal cofactors of enzymes
7. Beri Beri
8. Lipid Profile
9. Limiting aminoacids
 10. Glucose 6 Phosopate dehydrogenase enzyme
 *******

Dr. MGR University Question Paper,Paper V – BIOCHEMISTRY – I,2012 Question Paper,FIRST M.B.B.S.

Dr. MGR University Question Paper
FIRST M.B.B.S. DEGREE EXAMINATION
Paper V – BIOCHEMISTRY – I
Q. P. Code : 524055
Time : 180 Minutes Maximum: 100 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Elaborate on: Pages Time Marks
 (Max.) (Max.) (Max.)
 1. What are the components of Mitochondrial Electron
 Transport Chain .Describe the events and inhibitors of
 Oxidative phosphorylation. 16 25 15
 2. Explain the significance and reactions of Hexose
 MonoPhosphate shunt and disorders associated to it. 16 25 15
II. Write notes on:
1. Isoenzymes of Lactate dehydrogenase and their significance. 3 8 5
2. Functions, Deficiency Symptoms of Vitamin Thiamine. 3 8 5
3. Calcium homeostasis and its disorder. 3 8 5
4. Metabolic adaptation in Fed state. 3 8 5
5. What are the various muco polysaccharides. Add a note
 on hyaluronic acid. 3 8 5
6. Line Weaver Burk’s Plot and its significance. 3 8 5
7. Enzymes, coenzymes, inhibitors of Pyruvate
 Dehydrogenase Reaction. 3 8 5
8. Alcohol metabolism. 3 8 5
9. Fredrickson’s classification of hyperlipprotenemias. 3 8 5
 10. Mention the types of heteropolysaccharides and their functions. 3 8 5
III. Short Answers on:
1. Cardiolipin. 1 5 2
2. Mention the types of fatty acid oxidation. 1 5 2
3. What are the products of Arachidonic acid? 1 5 2
4. Carnitine. 1 5 2
5. Anomerism. 1 5 2
6. How Haemoglobin binds to oxygen. 1 5 2
7. Km Value and its significance. 1 5 2
8. Bronze Diabetes. 1 5 2
9. WHO criteria for Diagnosis of Diabetes mellitus. 1 5 2
 10. Zellweger’s syndrome. 1 5 2
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