Thursday, January 7, 2016

2014 Question Paper,FIRST M.B.B.S.,Paper V – BIOCHEMISTRY – I,Dr. MGR University Question Paper

Dr. MGR University Question Paper
Q. P. Code : 524055
Time : 180 Minutes Maximum: 50 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Elaborate on: (2 x 7.5 = 15)
 1. Describe the synthesis of glucose from alanine and mention its regulation.
 2. How are low-density lipoproteins (LDL) produced in the body?
 Describe, with the help of a diagram, their metabolic fate.
 What determines this process of their metabolic fate?
 Explain the clinical significance of this lipoprotein.
II. Write notes on: (10 x 2.5 = 25)
1. Name 5 enzymes, serum levels of which are increased in disease conditions, along with the
corresponding disease condition where such changes are seen.
2. Briefly explain the chemiosmotic hypothesis of Mitchell.
3. What is meant by dietary fibre? Explain its importance in one’s diet.
4. Explain the folate trap hypothesis.
5. What is surfactant? Explain its importance in the body in health and disease.
6. Explain, with a diagram, the fluid mosaic model of cell membranes.
7. What are good dietary sources of iron?
 Explain how iron is absorbed from the gastrointestinal tract.
8. Explain how the activity of an enzyme is affected by the pH of the medium.
9. What are the functions of calcium in the body?
 10. Describe the functions and deficiency manifestations of vitamin A.
III. Short Answers on: (10 x 1 = 10)
1. Explain the mechanism of action of cyanide as a poison.
2. List 2 differences between hexokinase and glucokinase.
3. Give 2 examples of drugs that act as inhibitors of enzyme and name the enzyme that each
one inhibits.
4. Explain the role of 2, 3 bisphosphoglycerate in supply of oxygen to tissue.
5. List 2 differences between foetal and adult forms of haemoglobin.
6. Why do patients with cholelithiasis often pass clay-coloured stools?
7. What is meant by the metabolic syndrome? What is the significance of this condition?
8. Write two functions & RDA of pyridoxine.
9. List 2 differences between marasmus and kwashiorkor?
 10. Give two examples of substrate level phosphorylation.
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