Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY,Dr. MGR University Question Paper,SECOND M.B.B.S.,2011 Question Paper

Dr. MGR University Question Paper
SECOND M.B.B.S. DEGREE EXAMINATION
Revised (Non-Semester) Regulations
Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY
Q. P. Code : 524063
Time : Three hours Maximum: 100 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Essay Questions : (2 x 15 = 30)
 1. Define inflammation.
 Write in detail about the vascular and cellular changes in inflammation.
 2. 40 yrs female c/o loss of weight, huge splenomegaly with peripheral blood white
 blood cell count of more than 1 lakh cells/cc
 a. What is the probable diagnosis?
 b. What are the characteristic peripheral smear findings?
 c. What is the course of the disease?
 d. What is the chromosomal abnormality involved?
II. Write Short notes on : (10 x 5 = 50)
1. Classify pigments and write about Lipofuschin.
2. Write about outcomes of acute inflammation.
3. Growth factors.
4. Hybridisation techniques to detect genomic alterations.
5. Antibody mediated hypersensitivity.
6. Molecular basis of cancer.
7. Immunology of Leprosy.
8. Primary myelofibrosis.
9. Hemophilia A.
 10. Peripheral smear and Bone marrow findings in Multiple Myeloma.
III. Short Answer questions : (10 x 2 = 20)
1. Define metaplasia and give two examples.
2. Antiphospholipid antibody syndrome.
3. Mention four X linked recessive disorders.
4. Mention four special stains for Amyloid.
5. Lead and blood and marrow changes.
6. Four infections associated with AIDS.
7. Hamartoma.
8. Prions.
9. Four Systemic effects of inflammation.
 10. Hyper IGM syndrome.
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Dr. MGR University Question Paper,Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY,2011 Question Paper,SECOND M.B.B.S.

Dr. MGR University Question Paper
SECOND M.B.B.S. DEGREE EXAMINATION
Revised (Non-Semester) Regulations
Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY
Q. P. Code : 524063
Time : Three hours Maximum: 100 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Essay Questions : (2 x 15 = 30)
 1. Define Necrosis. Name the different types of necrosis.
 Discuss in detail with examples the different types of necrosis.
 Differentiate between Necrosis and Apoptosis.
 2. A 70 year old women admitted with worsening anemia and pathological fracture of
 the Humerus had an ESR of 120mm in 1 hour. Her peripheral smear showed
 increased rouleaux formation. Xray of skull showed multiple punched out osteolytic
 lesions.
 a. What is the most probable diagnosis? Write briefly on the etiopathogenesis of this
 disease.
 b. Describe the Bone Marrow Changes in this disease.
 c. Enumerate the common laboratory investigations for this disease.
 d. Enlist the complications of this disease.
II. Write Short notes on : (10 x 5 = 50)
 1. Role of Arachidonic Metabolites in inflammation.
 2. Pathogenesis of Septic Shock.
 3. Tumour Metastasis.
 4. Mitochondrial Inheritance.
 5. Etiopathogenesis of Cystic Fibrosis.
 6. Anemia of Chronic Disease.
 7. FAB classification of Acute Leukemia.
 8. Idiopathic Thrombocytopenic purpura.
 9. Transfusion Reaction.
 10. Hematocrit.
III. Short Answer Questions : (10 x 2 = 20)
1. Give four examples for pathological calcification.
2. Give four examples for Metaplasia.
3. Mention two differences between exudates and transudate.
4. Mention two renal changes in SLE.
5. Give two examples for trace elements and their deficiency states.
6. Give four causes for iron deficiency anaemia.
7. Mention two important marrow changes in B12 deficiency.
8. Two characteristic difference between Myeloblasts and Lymphoblasts.
9. Mention two pathognomonic features of Hairy cell leukemia.
 10. Mention four applications of reticulocyte count.
******* 

2010 Question Paper,SECOND M.B.B.S.,Dr. MGR University Question Paper,Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY

Dr. MGR University Question Paper
SECOND M.B.B.S. DEGREE EXAMINATION
Revised (Non-Semester) Regulations
Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY
Q. P. Code : 524063
Time : Three hours Maximum: 100 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Essay Questions : (2 x 15 = 30)
 1. Define inflammation.
 Describe the major events of acute inflammation with a note on defective Leukocyte
 function.
 2. Enumerate the various carcinogenic agents.
 Classify the chemical carcinogens and describe the steps involved in chemical
 carcinogenesis.
II. Write Short notes on : (10 x 5 = 50)
1. Free Radical Injury.
2. Septic Shock.
3. Rickets.
4. Tertiary Syphilis.
5. Proteins in urine.
6. Cardiac edema.
7. Klinefelter syndrome.
8. Type I hypersensitivity reaction.
9. Factors affecting wound healing.
 10. Apoptosis.
III. Short Answers Questions: (10 x 2 = 20)
1. Sago Spleen.
2. Paraneoplastic syndromes.
3. ESR.
4. Coomb’s Test.
5. Reed Sternberg Cell
6. Hemophilia.
7. Metaplasia.
8. CVC liver.
9. Blood picture in megaloblastic Anemia.
 10. CSF in tuberculous meningitis.
*******

Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY,Dr. MGR University Question Paper,2010 Question Paper,SECOND M.B.B.S.,

Dr. MGR University Question Paper
SECOND M.B.B.S. DEGREE EXAMINATION
Revised (Non-Semester) Regulations
Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY
Q. P. Code : 524063
Time : Three hours Maximum: 100 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Essay Questions : (2 x 15 = 30)
 1. Define Oedema. Discuss the pathophysiology of oedema.
 Add a note on pulmonary oedema.
 2. Define and classify Leukemias.
 Describe the blood and bone morrow findings in chronic myeloid leukemia.
II. Write Short notes on : (10 x 5 = 50)
 1. Phagocytosis.
 2. Haematocrit.
 3. Sickle cell.
 4. Tumour suppressor genes.
 5. Anaphylactic reaction.
 6. Down’s syndrome.
 7. Metaplasia.
 8. Kwashiorkar.
 9. Mycetoma.
 10. Eosinophilia.
III. Short Answer Questions : (10 x 2 = 20)
 1. Name four causes of fatty liver.
 2. State four differences between dry and wet gangrenes.
 3. Define atrophy. Give two examples to physiological atrophy.
 4. Describe four staining character of amyloid.
 5. Microscopic appearance of lepromatous leprosy.
 6. Name two opportunistic infections and two neoplasms seen in AIDS.
 7. Name two human oncogenic viruses and tumours caused by them
 8. Blood components prepared in a blood bank.
 9. What is a Reticulocyte? Mention two causes of reticulocytosis.
 10. What is cross matching?
******* 

Dr. MGR University Question Paper,Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY,SECOND M.B.B.S.,2009 Question Paper

Dr. MGR University Question Paper
SECOND M.B.B.S. DEGREE EXAMINATION
Revised (Non-Semester) Regulations
Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY
Q. P. Code : 524063
Time : Three hours Maximum: 100 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Essay Questions : (2 x 15 = 30)
 1. Define and classify oedema? Discuss Aetio-Pathogenesis and pathology of various
 types of oedema with examples?.
 2. 40 years male H/o chronic fatigue, weight loss since 6 months. O/E pallor, marked
 splenomegaly+, laboratory report shows Hb 10 GM%, TC 215000/CMM.
 Platelets 4 laks/cmm. Answer the following:
 a) What is your diagnosis?
 b) What is common genetic abnormality?
 c) Blood and Bone Marrow findings to confirm your diagnosis?
 d) Prognosis of the condition?
II. Write Short notes on : (10 x 5 = 50)
1. Chemical mediators of acute inflammation.
2. Thrombo-embolism.
3. Pathological calcification.
4. Trisomy – 21.
5. Immune complex hypersensitivity (Type III) reactions.
6. Laboratory diagnosis of cancer.
7. Von-Willebrand’s disease.
8. Haemolytic disease of newborn.
9. Grading and staging of tumors.
10. Automatic tissue processor.
III. Short Answer Questions : (10 x 2 = 20)
1. Difference between exudates and transudate.
2. Microscopic picture of acute appendicitis.
3. Mast cells.
4. Mention four neuclear changes in Necrosis.
5. Significance of casts in urine.
6. Anti-Coagulants.
7. Mention four indications of bone marrow aspiration.
8. Reticulocyte count.
9. Henoch – Schonlein purpura.
 10. Gross appearance of Mycetoma foot.
******* 

2008 Question Paper,SECOND M.B.B.S.,Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY,Dr. MGR University Question Paper

Dr. MGR University Question Paper
SECOND M.B.B.S. DEGREE EXAMINATION
Revised (Non-Semester) Regulations
Paper III – GENERAL PATHOLOGY AND HAEMATOLOGY
Q. P. Code : 524063
Time : Three hours Maximum: 100 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Essay Questions : (2 x 15 = 30)
 1. What is Metastasis.
 What are the different pathways of spread?
 Write in detail about one of the pathways
 2. Define anemia.
 Discuss etiopathogenesis with blood and bone morrow picture in iron deficiency
 anemia.
II. Write Short notes on : (10 x 5 = 50)
1. Free radicals.
2. Wilm’s tumour.
 3. Klinefelter syndrome.
4. Oncogenic viruses.
5. Rhinosporidiosis.
6. Ricketts.
7. Fine Needle Aspiration Cytology
8. Leukemoid reaction.
9. Idiopathic thrombocytopenic purpura.
 10. Erythrocyte sedimentation rate.
III. Short Answer Questions : (10 x 2 = 20)
1. What are the different types of necrosis?
2. Mention 4 factors influencing wound healing.
3. Fate of thrombi.
4. Enumerate 4 types of chromosomal rearrangements.
5. Mention 2 Examples of tumor suppressor genes.
6. Mention any 4 childhood malignancies.
7. What are red cell indices?
8. Blood picture in magaloblastic anemia.
9. Mention important investigations necessary for diagnosis of Hemophilia.
 10. Define Leukemia.
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