PHARMACEUTICAL CHEMISTRY – I,University Of Pune Question Paper,2010 Question Paper,First Year B.Pharmacy

University Of Pune Question Paper
First Year B.Pharmacy Examination, 2010
PHARMACEUTICAL CHEMISTRY – I (2004 Course)
(Inorganic)
Time : 3 Hours Max. Marks : 80
 Instructions : 1) Question No. 1 from Section I and Question No. 5 from
Section II are compulsory.
2) Out of remaining questions solve 2 questions from Section
I and 2 questions from Section II.
3) Answers to the two Sections should be written in separate
books.
4) Figure to the right indicate full marks.
SECTION – I
1. a) Discuss the role of major extracellular and intracellular electrolytes. 8
b) Write principle involved in limit test for lead. 2
2. a) Explain role of fluoride and phosphate in tooth decay. 5
b) Define hardness of water and state the methods to remove hardness of
water. 5
c) What is radiopaque contrast media ? Explain barium sulphate as radiopaque
contrast media. 5
3. a) Explain the role of Iron in body. 5
b) Enlist sources of impurities in pharmaceutical substances and explain their
effect on pharmaceutical substances. 5
c) Describe limit test for Iron. 5
4. a) Define antidote, discuss different antidotes with their mechanism of
action. 5
b) Define monograph. Elaborate contents of monograph. 5
c) Discuss in brief applications of radiopharmaceuticals. 5
SECTION – II
5. a) What are protective and adsorbents ? Describe two official compounds used
as protective. 5
b) Define the terms buffer, emetics, cathartics, antacid and expectorant. 5
6. a) Classify topical agents on the basis of their actions with example. 5
b) Discuss in brief antioxidants. 5
c) Define and classify inorganic Gastrointestinal agents. 5
7. Write short notes on (any five) : 15
a) Astringents
b) Protectives
c) Assay of KI
d) Assay of NH4
Cl
e) Combination Antacids
f) Preservatives.
8. a) Discuss in brief antimicrobial agents. 5
b) Discuss the source, physiological importance and compounds of Iodine. 5
c) Explain the role of oxygen, carbon dioxide in human body. 5
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2010 Question Paper,University Of Pune Question Paper,PHARMACEUTICS – I,First Year B.Pharmacy

University Of Pune Question Paper
First Year B.Pharmacy Examination, 2010
PHARMACEUTICS – I
(Including Community Pharmacy) (2004 Courses)
Time : 3 Hours Max. Marks : 80
 Instructions : 1) Question Nos. 1 and 5 are compulsory. Out of the
remaining attempt 2 questions from Section I and
2 questions from Section II.
2) Answers to the two Sections should be written in
separate books.
3) Neat diagrams must be drawn whenever necessary.
4) Black figures to the right indicate full marks.
SECTION – I
1. a) Define drug, dosage form and explore the concept of formulation. Explain
factors affecting drug absorption. 6
b) Explain the methods of prevention of aeration and foam during liquid
mixing. 4
2. Explain the physiological factors affecting drug bioavailability. 15
3. a) Explain the fate of drug in the body. 6
b) Explain the manufacturing process and equipments used in the manufacturing
of solution. 9
4. Write short notes on -(any three) : 15
a) Mouth washes
b) Plate and frame filter
c) Passive diffusion as mechanism for drug absorption
d) Syrup.
SECTION – II
5. Define size separation, write the importance of size separation. Explain the cyclone
separator in detail. 10
6. a) Explain in detail GMP requirements for manufacturing of pharmaceuticals. 8
b) What is Pharmacopeia ? Give the importance of different Pharmacopeias. 7
7. a) Explain dry and wet granulation methods. 9
b) Explain in detail Fluid energy mill. 6
8. Write short notes on (any three) : 15
a) Role of community pharmacist in management of communicable diseases
b) Dusting powder
c) Hammer mill
d) Ayurvedic system of medicine.
____________

First Year B.Pharmacy, 2010 Question Paper,1.7 : COMPUTER APPLICATIONS AND BIO-STATISTICS,University Of Pune Question Paper

University Of Pune Question Paper
First Year B.Pharmacy Examination, 2010
1.7 : COMPUTER APPLICATIONS AND BIO-STATISTICS
(2008 Pattern)
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question Nos. 1 and 5 are compulsory. Out of the remaining
attempt two questions from Section I and two questions from
Section II.
2) Answers to the two Sections should be written in separate
books.
3) Neat diagram must be drawn whenever necessary.
4) Black figures to the right indicate full marks.
SECTION – I
1. A) Calculate the geometric mean of the salaries of workers given below : 5
Salary
(Rs.) 100-110 110-120 120-130 130-140 140-150 150-160
No. of
Workers 14        16          30         20             15         5
B) Draw a frequency polygon from the following data : 4
Age 10-12 12-14 14-16 16-18 18-20 20-22 22-24
No. of
Students 4 10 16 30 20 14 6
C) What are sampling and non sampling errors ? 3
2. A) The median and mode of the following distribution are 27 and 26. Calculate
the missing frequency. 5
Class interval 0-10 10-20 20-30 30-40 40-50
Frequencies 4 ? 20 ? 8
B) Calculate standard deviation from the following data : 5
Marks 0-10 10-20 20-30 30-40 40-50
No. of Students 24842
C) Define “measure of dispersion”. What are the requirements of a good measure
of dispersion ? 4
3. A) A bag contains 8 white and 4 red balls. Five balls are drawn at random. What
is the probability that 2 of them are red and 3 white ? 5
B) Enlist different types of Non-Parametric tests. And give the advantages of
non-parametric tests. 4
C) Calculate the person correlation coefficient between the ages of the plants and
their heights. 5
Age in week (x) 1234567
Height in c.m. 5 13 16 23 33 38 40
4. A) In binomial distribution with 6 independent trials the probabilities of 3 and 4
successes are found to be 0.2457 and 0.0819 respectively. Find the parameter
p of the distribution. 4
B) Write a short note on critical region. 5
C) Given the following data x =36 y =85 σ x = 11 σ y = 8 and r = 0.66 find the
regression equation and estimate x when y = 75. 5
SECTION – II
5. A) How many computer generation have evolved until now ? Explain each. 5
B) Define following terms :
i) Compiler ii) Interpreters
iii) RAM iv) Software 4
C) Differentiate between DOS and Unix Operating System. 3
6. A) Explain the option “Format” in MS-Word. 5
B) Convert (100111)2 binary number to its Octal equivalent. 4
C) Which software is used for preparing presentation slides ? Explain. 5
7. A) State the steps to copy the contents of cell to another cell. 4
B) Write a short note on : 10
i) Keyboard ii) CD-ROM.
8. A) Define Operating System. Give three example of any operating system. 5
B) Explain multitasking ability of the windows. 4
C) Explain the operations of mouse. 5

2010 Question Paper,University Of Pune Question Paper,1.6 : PHARMACEUTICAL ENGINEERING,First Year B.Pharmacy

University Of Pune Question Paper
First Year B.Pharmacy Examination, 2010
1.6 : PHARMACEUTICAL ENGINEERING
(2008 Pattern)
Time : 3 Hours Max. Marks : 80
 Instructions : 1) Answers to the two Sections should be written in
separate books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All questions are compulsory.
SECTION – I
1. Give different mechanisms of heat transfer. Explain Fourier’s law in detail. 10
OR
Explain crystallization by evaporation and describe circulating magma crystallizer.
2. Answer the following (any five) : 15
a) Mechanical steam trap.
b) Tank crystallizer.
c) Environmental controls in pharmaceutical Industry.
d) Pan evaporator.
e) Define humidity and percent relative humidity.
f) Boiling inside a vertical tube.
g) Agitated tank crystallizer.
3. Write short notes on (any three) : 15
a) Kirchoff’s law of heat transfer.
b) Tubular heat exchangers.
c) Crystal forms.
d) Swenson-Walker crystallizer.
e) Climbing Film evaporator.
SECTION – II
4. Derive Bernoulli’s equation for flow of fluids and describe various types of energy
losses in fluid flow. 10
OR
Define distillation. Compare distillation and evaporation. Discuss boiling point
diagram and equilibrium curve.
5. Answer the following (any five) : 15
a) Inclined manometer.
b) Basket extractor.
c) Bubble cap plate column.
d) Fluidized bed dryer.
e) Drum dryer.
f) Material selection in preventing corrosion.
g) Galvanic corrosion.
6. Write short notes on (any three) : 15
a) Venturi meter.
b) Disc meter.
c) Robert diffusion battery.
d) Molecular diffusion in mass transfer.
e) Distillation under reduced pressure.
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1.4 : PHARMACEUTICAL ORGANIC CHEMISTRY – I, 2010 Question Paper,First Year B.Pharmacy,University Of Pune Question Paper

University Of Pune Question Paper
First Year B.Pharmacy Examination, 2010
1.4 : PHARMACEUTICAL ORGANIC CHEMISTRY – I
(2008 Pattern)
Time: 3 Hours Total Marks: 80
Instructions : 1) All questions are compulsory.
2) Answer to the two Sections should be written in separate
books.
3) Black figures to the right indicate full marks.
SECTION – I
1. A) Explain the mechanism involved in Friedel Craft acylation and nitration of
Benzene. 10
OR
B) Explain substitution nucleofilic unimolecular reaction mechanism with
stereochemistry with suitable examples.
2. A) Draw the structure of following compound (any 3) : 3
a) 2, 4 Hexadione
b) Methyl-2- butnenoate
c) Cyclopropane carboxilic acid
d) 3-Methyl-4-pentene-2-one.
B) Answer the following (any four) : 12
1) Define and illustrate Tautamerism.
2) Compare the stability of primary, secondary and tertiary, carbonium ion.
3) What is Inductive effect and explain it with suitable example.
4) What is difference between nucleophilicity and basisity ?
5) Draw as much resonance structure as you can for following
a) Anilline
b) Acetic acid.
6) Explain Huckels rule for aromaticity with suitable example.
3. Answer the following (any three) : 15
1) What is resonance ? Explain the rules of resonance with suitable example.
2) Compare SN1 and SN2 mechanism.
3) Write a synthesis of following compound starting with Benzene and with
suitable reagent
a) Para nitro toluene
b) Meta nitro toluene.
4) Write a note on optical isomerism. Explain it with a suitable example.
5) Define the following terms and give any two suitable examples of each
a) Activating group
b) Deactivating group
c) Ortho and para director.
SECTION – II
4. A) What are elimination reactions ? Discuss the Mechanism, stereochemistry,
kinetics and orientation involved in elimination reaction. 10
OR
A) Explain why aldehydes are more reactive than ketone for nucleophilic addition
reaction and add a note on addition of hydrogen cynide to aldehyde.
5. Answer the following (any five) : 15
1) How will you differentiate the following pair of compounds by simple chemical
test ?
a) Pentanal and Pentanone
b) Aniline and Phenol.
2) Explain hydrogenation reaction with C-C multiple bond.
3) Why esters are less reactive towards nucleophile than aldehydes ?
4) Arrange the following compounds in order of increasing acidity.
a) Acetic acid
b) Chloro acetic acid
c) formic acid.
5) Describe how primary, secondary and tertiary amines can be separated from
mixture.
6) Explain Canizarros reaction with mechanism.
7) Give any two method of synthesis of carboxylic acids.
6. Write note on (any 3) : 15
1) Preparation of Sulphonic acid.
2) Reaction of phenols.
3) Ozonolysis.
4) Saytzaffs and Hoffmann elimination.
5) Knovengel condensation.
——————

2010 Question Paper,First Year B.Pharmacy,University Of Pune Question Paper,1.3 : PHARMACEUTICAL INORGANIC CHEMISTRY

University Of Pune Question Paper
First Year B.Pharmacy Examination, 2010
1.3 : PHARMACEUTICAL INORGANIC CHEMISTRY
(2008 Pattern)
Time : 3 Hours Max. Marks : 80
Instructions : 1) All questions are compulsory.
2) Answers to the two Sections should be written in separate
answer books.
3) Figures to the right indicate full marks.
SECTION – I
1. What is radioactive decay ? Discuss the properties of  ,
and
radiations. 10
OR
1. Explain the terms ‘pharmacopoeia’ and ‘monograph’. Enlist different
Pharmacopoeias and discuss salient features of monograph. 10
2. Attempt any five of the following : 15
a) Explain the limit for chloride for potassium permanganate as per IP.
b) Why the tube is packed with dried cotton wool impregnated with lead acetate
solution while carrying out limit test for arsenic ?
c) Explain the terms hydrogen ion concentration, pH and pOH.
d) Explain the terms buffer action and buffer capacity.
e) Discuss the role of oxygen in biological system.
f) Give the properties, uses and method of assay of ammonia.
g) Write in brief about adsorbents.
3. Write notes on any three of the following : 15
a) Water as pharmaceutical vehicle
b) Discuss role of buffers in pharmacy.
c) Storage conditions as detailed in I.P.
d) Raw materials as source of impurities in pharmaceuticals.
e) Methods of softening water.
SECTION – II
4. How the acid base balance of the body is maintained ? 10
OR
4. Discuss the mechanism of action of topical protective agents with examples.
Explain the properties, uses and method of assay of talc and zinc oxide.
5. Attempt any five of the following : 15
a) Explain the term milliequivalent. Calculate the number of mEq of potassium
chloride in one liter of a 0.48% w/v solution.
b) List the compounds of calcium and magnesium used as antacid.
c) Explain assay of ferrous sulphate, along with reactions.
d) Discuss mechanism of action of anti-caries agents.
e) Describe preparation and mechanism of action of antimony potassium tartarate.
f) Define antidotes and explain their mechanism of action.
g) Describe with principle and reactions assay of ammonium chloride.
5. Write notes on any three of the following : 15
a) Electrolyte combination therapy
b) Ideal properties of antacids
c) Antidotes
d) Physiological role of copper
e) Saline cathartics
–––––––––––––
B/

First Year B.Pharmacy,1.3 : PHARMACEUTICAL INORGANIC CHEMISTRY,2012 Question Paper,University Of Pune Question Paper

University Of Pune Question Paper
First Year B.Pharmacy Examination, 2012
1.3 : PHARMACEUTICAL INORGANIC CHEMISTRY
(2008 Pattern)
Time : 3 Hours Max. Marks : 80
Instructions : 1) All questions are compulsory.
2) Answers to the two Sections should be written in separate
answer books.
3) Figures to the right indicate full marks.
SECTION – I
1. Define preservative. Explain role of preservatives as pharmaceuticals necessities
with examples. 10
OR
1. Give definition and classification of official waters, explain different quality control
test for water as per I.P. 10
2. Attempt any five of the following : 15
a) Give classification of antioxidants.
b) Write properties and mode of actions of antacids.
c) Assay of Ferrous sulphate as per I.P.
d) Explain astringents.
e) Physiological role of 14-iodine.
f) Write properties and mode of actions of hydrogen peroxide solution.
g) Write the limit test for heavy metals as per I.P.
3. Write notes on any three of the following : 15
a) Essential and trace ions
b) Water for injections
c) Pharmaceutical application of electrolytes
d) Nitrous oxide gas
e) Sodium nitrite as an antidote.
SECTION – II
4. Define and discuss about acid, base and buffers, explain how it used as
pharmaceutical necessities with examples. 10
OR
4. Give classification of gastrointestinal agents; explain pharmaceutical applications
and mechanism actions of acidifying agents. 10
5. Attempt any five of the following : 15
a) Quality control test for soft water.
b) Explain nuclear reaction.
c) Physiological role of protective agents.
d) Physiological acid base balance.
e) Application of bismuth sodium tartarate.
f) Define antacid; write properties of aluminum hydroxide.
g) Pharmaceutical advantages of topical preparations.
6. Write notes on any three of the following : 15
a) Application of radiopharmaceuticals.
b) Factors affecting purity of pharmaceuticals.
c) Physiological role of sodium ion (Na) and potassium ion (K) as an electrolyte.
d) Ammonia gas as an important inorganic gas.
e) Dental products.
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1.1 : PHARMACEUTICS – I,First Year B.Pharmacy,University Of Pune Question Paper,2012 Question Paper

University Of Pune Question Paper
First Year B.Pharmacy Examination, 2012
1.1 : PHARMACEUTICS – I(2008 Pattern)
Time : 3 Hours Max. Marks : 80
Instructions : 1) Answer to the two Sections should be written in separate
books.
2) Neat diagrams must be drawn wherever necessary.
SECTION – I
1. Define dosage form. Classify dosage form on the basis of route of administration
with suitable example. Also explain need to design dosage form. 10
OR
What are the clinical trials ? Explain phases of clinical trials in detail.
2. Answer the following (any 5) : 15
a) Briefly write about the types of containers.
b) Explain any two methods to enhance solubility of poorly water soluble drugs.
c) Define preformulation and explain bulk density and angle of repose.
d) Mention applications of Radiopharmaceuticals.
e) What is Bioavailability and Bioequivalence ?
f) Explain Sidha and Unani as alternative system of medicine.
g) What guidelines under the GMP to be followed by the pharmaceutical industry ?
3. Write a short note on (any three) : 15
a) Steps for new drug application
b) NDDS
c) Development of IP
d) Scope of pharmaceutics
e) Glass as packaging material.
SECTION – II
1. What is need of Granulation ? Explain different methods of granulation. 10
OR
What is Solution ? Explain in detail the factors affecting rate of solutions.
2. Answer the following (any 5) : 15
a) What are Elixirs ? Explain two methods of preparation of elixirs.
b) Define sieve number. What are the different grades of powder as per I.P. ?
c) What is size reduction ? Mention the factors affecting size reduction.
d) Explain in brief powder mixing mechanism.
e) Write in brief about propeller mixer.
f) Write in brief about the factors which affects rate of filtration
g) Explain rotary drum dryer.
3. Write a short note on (any three) : 15
a) Size distribution methods
b) Dusting powders
c) Fluid energy mill
d) Pouch filling machine
e) Tumbler mixer.
————————
B

2013 Question Paper,University Of Pune Question Paper,PHARMACOGNOSY – I,First Year B.Pharmacy

University Of Pune Question Paper
First Year B.Pharmacy Examination, 2013
PHARMACOGNOSY – I
(Old Course) (2004 Pattern)
Time : 3 Hours Max. Marks : 80
Note :1) Question No. 1 and 5 are compulsory.
2) Out of remaining attempt any two questions from Section – I and
any two questions from Section – II
3) Answers to the two Sections should be written in separate books.
4) Figures to right indicate full marks.

SECTION – I
I. a) Define evaluation of crude drug. Describe in detail Physical evaluation. 6
b) Write a note on Stomata. 4
II. a) Give the advantages of the cultivation of crude drugs and explain the factors
affecting the cultivation of medicinal plants. 8
b) Describe the morphology and anatomy of Roots. 7
III. a) Explain different types of propagation of crude drugs with their merits and
demerits. 8
b) Discuss different types of classification of crude drugs. 7
IV. Write short notes (any three) : 15
i) Gum Acacia
ii) Fundamental tissue system
iii) Differentiate between Organized and Unorganized crude drugs
iv) Extractive values.