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Dr. A.P.J. Abdul Kalam University D PHARMA II SEM Pharmacology & Toxicology [DPY203] April 2021 Question Paper

Dr. A.P.J. Abdul Kalam University

Diploma in Pharmacy

Second Year Main Examination, April-2021

Pharmacology & Toxicology [DPY203]

Time: 3:00 Hrs Max Marks 80

Note : Attempt all questions.

Each question carries equal marks.

Q.1 Multiple Choice Question. 1x16

(i) Autacoids differ from hormones in that:

(a) Autacoids are involved only in the causation of pathological states

(b) Autacoids do not have a specific cell/tissue of origin

(c) Autacoids generally act locally at the site of generation and release

(d) Both ‘B’ and ‘C’ are correct

(ii) Which of the following is a selective H1 receptor agonist:

(a) 4-methyl histamine (b) Impromidine

(c) 2-Thiazolyl ethylamine (d) Chlorpheniramine

(iii) Histamine exerts the following actions except:

(a) Dilatation of large blood vessels

(b) Dilatation of small blood vessels

(c) Stimulation of isolated guineapig heart

(d) Itching

(iv) Fall in blood pressure caused by larger doses of histamine is blocked by:

(a) H1 antihistaminics alone

(b) H2 antagonists alone

(c) Combination of H1 and H2 antagonists

(d) None of the above

(v) Histamine is involved as a mediator in the following pathological condition:

(a) Delayed hypersensitivity reaction (b) Inflammation

(c) Carcinoid syndrome (d) Variant angina

(vi) The drug that can directly release histamine from mast cells without involving antigen-antibody

reaction is:

(a) Aspirin (b) Procaine

(c) Morphine (d) Sulfadiazine

(vii) High anticholinergic property is present in the following antihistaminic:

(a) Diphenhydramine (b) Astemizole

(c) Cetirizine (d) Terfenadine

(viii) The following H1 antihistaminic has additional anti 5-HT, anticholinergic, sedative and appetite

stimulating properties:

(a) Promethazine (b) Terfenadine

(c) Cyproheptadine (d) Hydroxyzine

(ix) While prescribing a first generation H1 antihistaminic the patient should be advised to avoid:

(a) Driving motor vehicles (b) Consuming processed cheese

(c) Strenuous physical exertion (d) All of the above

(x) Select the H1 antihistaminic which is used topically in the nose for allergic rhinitis:

(a) Loratadine (b) Cetirizine

(c) Fexofenadine (d) Azelastine

(xi) The smooth muscle stimulating action of 5-HT is most marked in the:

(a) Bronchi (b) Intestines

(c) Ureter (d) Biliary tract

(xii) The ‘amine’ ergot alkaloid differs from ‘amino acid’ ergot alkaloid in that it has:

(a) High oral bioavailability (b) Better CNS penetrability

(c) Weaker oxytocic action (d) Strong anti-5-HT action

(xiii) The primary route of administration of insulin is:

(a) Intradermal (b) Subcutaneous

(c) Intramuscular (d) Intravenous

(xiv) The most common adverse reaction to insulin is:

(a) Hypoglycaemia (b) Lipodystrophy

(c) Urticaria (d) Angioedema

(xv) Which of the following is a neuroglucopenic symptom of hypoglycaemia:

(a) Sweating (b) Palpitation

(c) Tremor (d) Abnormal behavior

(xvi) Insulin resistance can be minimized by the use of:

(a) Corticosteroids (b) Tolbutamide

(c) Protamine (d) Monocomponent/Human insulin

Q.2 (a) Discuss the definition of pharmacology and scope of pharmacology

(b) Write the concepts of essential drug with example

Q.3 (a) Write brief note on routes of drug administration with example

(b) Write detail about agonists, antagonists with example.

Q.4 (a) Write detail about tachyphylaxis, idiosyncrasy, and allergy with example

(b)What is Pharmacokinetics? Discuss the absorption, distribution,

metabolism and excretion of drugs

Q.5 (a) Write detail about G-protein–coupled receptors & ion channel receptor with example

(b) Write the dose response relationship and therapeutic index.

Q.6 (a) Write detail about adverse drug reactions.

(b) Write detail about Drug interactions with example

Q.7 (a) Write the brief process of drug discovery, Describe the phases of clinical trials.

(b) Write detail classification of neurotransmitters.

Q.8 (a) Write differences between Parasympathomimetics and Parasympatholytics with example

(b) Write differences between Sympathomimetics, and sympatholytics with example

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