Dr. MGR University OCTOBER 2011 Question Paper
Subject : PAPER I – PHARMACOLOGY - II
[KZ 813] OCTOBER 2011 Sub. Code: 3813DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER I – PHARMACOLOGY - II
Q.P. Code: 383813
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. Classify diuretics according to their sites of action.
Explain the mechanism of action, pharmacological effects, 17 40 min. 20
therapeutic uses and adverse effects of loop diuretics.
2. Define signal transduction. Mention various kinase pathways.
Explain any two kinase pathways. 17 40 min. 20
II. Write notes on :
1. Clopidogrel. 4 10 min. 6
2. Receptors and therapeutic uses of vasopressin. 4 10 min. 6
3. Tetracycline. 4 10 min. 6
4. Amphotericin B. 4 10 min. 6
5. Nucleoside and nucleotide reverse transcriptase inhibitors. 4 10 min. 6
6. Monoclonal antibodies as immunosuppressants. 4 10 min. 6
7. Acute toxicity studies. 4 10 min. 6
8. Cell cycle regulators and modifiers. 4 10 min. 6
9. Histone deactyalses. 4 10 min. 6
10. Altered gene functions. 4 10 min. 6
*******
Dr. MGR University APRIL 2012 Question Paper
Subject : PAPER I – PHARMACOLOGY - II
[LA 813] Sub. Code: 3813DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER I – PHARMACOLOGY - II
Q.P. Code: 383813
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. Define antibiotics. Explain the general mechanism of
action of various antibacterial agents. 17 40 min. 20
Discuss the pharmacology of penicillins.
2. Explain gene transcription and various factors that
regulate transcription. 17 40 min. 20
II. Write notes on :
1. Mechanism of action and drug interactions involving warfarin. 4 10 min. 6
2. Potassium-sparing diuretics. 4 10 min. 6
3. Aminoglycoside antibiotics. 4 10 min. 6
4. Classify anti leprotic drugs and discuss about dapsone. 4 10 min. 6
5. Calcineurin inhibitors. 4 10 min. 6
6. Chronic toxicity studies. 4 10 min. 6
7. Ion channels. 4 10 min. 6
8. MAP kinase pathway. 4 10 min. 6
9. Biosensors. 4 10 min. 6
10. Gene therapy. 4 10 min. 6
*******
Dr. MGR University OCTOBER 2012 Question Paper
Subject : PAPER I – PHARMACOLOGY - II
[LB 813] Sub. Code: 3813DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER I – PHARMACOLOGY - II
Q.P. Code: 383813
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. a) Classify anti-neoplastic agents with examples. 17 40 min. 20
b) Write the mechanism of action, therapeutic uses of
methotrexate.
c) Discuss in detail about general toxicity of cytotoxic agents.
2. Define Protein. Discuss the mechanism and various 17 40 min. 20
steps involved in Protein synthesis.
II. Write notes on :
1. Give the category, mechanism of action and side effects
of Tacrolimus. 4 10 min. 6
2. Write a note on Mutation. 4 10 min. 6
3. Give the mechanism of action and side effects of co-trimoxazole. 4 10 min. 6
4. Give the therapeutic uses and mechanism of actions
of metronidazole and pyrimethamine. 4 10 min. 6
5. Write the therapeutic uses of ciprofloxacin. 4 10 min. 6
6. Write a note on Heparin antagonist. 4 10 min. 6
7. Write a note on haematinics. 4 10 min. 6
8. Classify diuretics with suitable example.
Give the therapeutic uses of thiazide diuretics. 4 10 min. 6
9. Write the mechanism of actions: 4 10 min. 6
(i) Acetazolamide (ii) Vasopressin (iii) Rifampicin.
10. Briefly explain (i) Translocation (ii) Tumour suppressor gene. 4 10 min. 6
*******
Dr. MGR University APRIL 2013 Question Paper
Subject : PAPER I – PHARMACOLOGY - II
[LC 813] Sub. Code: 3813DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER I – PHARMACOLOGY - II
Q.P. Code: 383813
Time: Three Hours Maximum: 100 marks
Answer All questions
I. Elaborate on: (2 x 20 = 40)
1. Discuss the life cycle of malarial parasite.
Classify anti-malarial drugs and explain mechanism of action, adverse effects and
therapeutic uses of chloroquine.
2. Discuss the recombinant DNA technology and its Pharmaceutical applications with
examples.
II. Write notes on: (10 x 6 = 60)
1. State the mechanism of action and advantage of low molecular Heparin.
2. Explain the mechanism of development of bacterial resistance to antibiotics.
3. Write a note on Biosensors.
4. Write a note on treatment of TB as per WHO.
5. Write a note on Oncogenes.
6. What are Plasma Expanders? Give its therapeutic uses.
7. Write a note on immunosuppressive corticosteroids.
8. Write a note on Furosemide.
9. What is chronic toxicity study? Explain its importance in preclinical studies.
10. What is Aldosterone antagonist? Give its mechanism of action and therapeutic uses.
*******
Dr. MGR University OCTOBER 2013 Question Paper
Subject : PAPER I – PHARMACOLOGY - II
[LD 813] Sub. Code: 3813DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER I – PHARMACOLOGY - II
Q.P. Code: 383813
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (2 x 20 = 40)
1. What are quinolones?
Write the spectrum of activity, mechanism of action therapeutic uses and adverse
reactions of ciprofloxacin.
2. Classify anti cancer drugs with suitable examples.
Write the mechanism of actions, therapeutic uses and adverse effects of paclitaxel.
Add a note on hormones as anticancer drugs.
II. Write notes on: (10 x 3 = 30)
1. Write a note on fibrinolytic agents.
2. Write a note on anti amoebic drugs.
3. Write a note on loop diuretics.
4. What are anti diuretic hormones? Give its therapeutic uses.
5. Write a note on acute toxicity studies.
6. What is DNA replication? Give its importance.
7. What are the vectors used in gene transfer?
8. Write a note on gene mapping.
9. What is mean by
a) Mutation
b) Deletion
c) Amplification?
10. What are macromolecules? Give its functions.
*******
Dr. MGR University APRIL 2014 Question Paper
Subject : PAPER I – PHARMACOLOGY - II
[LE 813] Sub. Code: 3813DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER I – PHARMACOLOGY - II
Q.P. Code: 383813
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (2 x 20 = 40)
1. Classify anticancer drugs.
Explain the pharmacology of alkylating agents.
2. What is recombinant technology?
Explain the principle, gene transfer technologies and applications of the same.
II. Write notes on: (10 x 3 = 30)
1. Oral anticoagulants.
2. Mechanism and therapeutic uses of vasopressin.
3. Antibiotic resistance.
4. Amphotericin.
5. m-TOR inhibitors.
6. Subacute toxicity studies.
7. Janus kinase pathway.
8. Histones.
9. Types of mutation.
10. Gene therapy targets.
*******
Dr. MGR University OCTOBER 2014 Question Paper
Subject : PAPER I – PHARMACOLOGY - II
[LF 813] Sub. Code: 3813DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(2009-2010 Regulation)
THIRD YEAR
PAPER I – PHARMACOLOGY - II
Q.P. Code: 383813
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (4 x 10 = 40)
1. What is cell signaling?
Explain any two kinase signal transduction pathway.
2. Discuss life cycle of malaria.
Classify the antimalarial drug and give pharmacology of chloroquine.
3. Classify the antiplatelet drug.
Write the mechanism of action, adverse drug reaction and therapeutic uses of
clopidogrel.
4. Define protein. Explain the mechanism and various steps involved in protein synthesis.
II. Write notes on: (6 x 5 = 30)
1. Recombinant technology and its application.
2. Histone deacetylase.
3. Classify the immunosuppressants and its clinical application.
4. Classify the protein synthesis inhibitors and give short note on tetracycline.
5. Write a note on plasma volume expander.
6. Potassium sparing diuretics.
*******
Dr. MGR University APRIL 2015 Question Paper
Subject : PAPER I – PHARMACOLOGY - II
[LG 813] Sub. Code: 3813DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(2009-2010 Regulation)
THIRD YEAR
PAPER I – PHARMACOLOGY - II
Q.P. Code: 383813
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (4 x 10 = 40)
1. What is recombinant technology?
Explain the principle, gene transfer technology and applications of the same.
2. Classify anticoagulants with examples and explain the pharmacology of heparin.
3. Classify anti-microbial agents with suitable examples and mechanism action of
tetracycline antibiotics.
4. Explain the pharmacology of furosemide.
II. Write notes on: (6 x 5 = 30)
1. Janus kinase pathway.
2. Gene therapy targets.
3. Write the therapeutic uses of ciprofloxacin.
4. Explain the importance of preclinical toxicity studies.
5. Write a note on co-trimoxazole.
6. Write a note on anti amoebic drugs.
*******
Dr. MGR University OCTOBER 2015 Question Paper
Subject : PAPER I – PHARMACOLOGY - II
[LH 813] Sub. Code: 3813PHARM. D DEGREE EXAMINATION
(2009-2010 Regulation)
THIRD YEAR
PAPER I – PHARMACOLOGY – II
Q.P. Code : 383813
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on : (4 x 10 = 40)
1. Explain gene transcription and various factors that regulate transcription.
2. Define cancer. Classify the anticancer drugs with example, write the Mechanism
and therapeutic uses of antimetabolite.
3. Classify the immunosuppressant. Write the mechanism of action, adverse drug
reaction, and therapeutic uses of mycophenolate mofetil.
4. Define diuretics. Classify the diuretic according to their site of action and brief the
loop diuretics.
II. Write notes on : (6 x 5 = 30)
1. Explain various mechanism of development of bacterial resistance to antibiotics.
2. Classify the anti TB Drugs. Write the treatment of TB as per DOTS.
3. Mutation.
4. Write note on Anticoagulants.
5. Define antidiuretic. Write receptor and clinical uses of vasopressin.
6. Brief the Nucleotide Reverse Transcriptase inhibitors.
*******
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