Monday, December 28, 2015

First Year B.Pharm.,PHARMACEUTICAL CHEMISTRY – II,2010 Question Paper,University Of Pune Question Paper

University Of Pune Question Paper
First Year B.Pharm. Examination, 2010
PHARMACEUTICAL CHEMISTRY – II
(Organic)
(2004 Course)
Instructions : 1) Question No. 1 and 5 are compulsory. Out of the remaining
attempt 2 questions from Section I and 2 questions from Section II.
2) Answers to the two Sections should be written in separate books.
3) Black figures to the right indicate full marks.
Time : 3 Hours Max. Marks : 80
SECTION – I
1. A) Define any four of the following : (4)
1) Carbocation
2) Stereochemistry
3) Inductive effect
4) Nucleophile
5) Tautomerism.
B) Draw the structures of following compounds (any four) : (4)
1) 2 amino benzonitrile.
2) Cyclohexane 1, 4, dicarboxylic acid.
3) Naphthalene 1, 8 disulfonic acid.
4) 1, 3, 5 trichloro benzene.
5) 2, 2, dichloropropionic acid.
C) What do you mean by Geometrical isomerism ? (2)
2. Give reasons (any 5) : (15)
i) Ammonia is a stronger base over aniline.
ii) p-nitrophenol is a stronger acid than phenol.
iii) Halogens though deactivators are O, P, directors in electrophilic aromatic
substitution.
iv) Aldehydes are more reactive than ketones.
v) Guanidine is one of the strongest organic base.
vi) Nitro benzene when reacted with Nitrating mixture gives m-dinitrobenzene.
3. a) Explain electrophilic aromatic substitution with respect to Nitration and
halogenation. (5)
b) Explain Electrophilic aromatic substitution in Napthalene. (5)
c) Explain SNi
 reaction. (5)
4. Write short notes on (any three) : (15)
i) Enantiomerism
ii) SN2 reaction
iii) Friedal Craft Alkylation
iv) Orientation in monosubstituted benzene.
SECTION – II
5. Define elimination reaction. Explain E1
 and E1cb reactions in detail. (10)
6. a) Explain addition reactions across C = O bond. (7)
b) Compare and contrast elimination and substitution reactions. (8)
7. a) Explain preparation of carboxylic acid derivatives. (5)
b) Explain cannizaro reaction with examples. (5)
c) Explain reactions of carboxylic acids. (5)
8. Starting from benzene or toulene and suitable reagents how will you synthesize
the following (give only reaction equations and reaction conditions.) Solve any five
of following : (15)
1) Anthranilic acid
2) P. nitro acetanilide
3) M-nitro benzoic acid
4) 2, 4, 6 trinitrophenol
5) P-aminophenol
6) Diphenyl ether.
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