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Monday, December 28, 2015

University Of Pune Question Paper,PHARMACEUTICS – V (Biopharmaceutics and Pharmacokinetics),2010 Question Paper,Fourth Year B. Pharm.

University Of Pune Question Paper
Fourth Year B. Pharm. Examination, 2010
PHARMACEUTICS – V
(Biopharmaceutics and Pharmacokinetics)
 (2004 Course)
Time : 3 Hours Max. Marks : 80
Instructions: 1) Question Nos. 1 and 5 are compulsory. Out of the remaining
attempt 2 questions from Section I and 2 questions from
Section II.
2) Answers to the two Sections should be written in separate
books.
3) Neat diagrams must be drawn wherever necessary.
4) Black figures to the right indicate full marks.
SECTION – I
1. a) Discuss the physicochemical factors affecting drug absorption. Highlight
diffusion layer model/film theory. 7
b) What is the influence of drug pka and GI pH on drug absorption ? 3
2. a) How the organ size and perfusion rate influence the drug distribution ? 7.5
b) Explain the different physiological barriers to the drug distribution. 7.5
3. a) How can the principle of binding be used for drug targetting ? Explain. 7.5
b) What is the influence of various disease states on plasma protein level and
drug binding ? 7.5
4. a) Write a note on BCS and BDDCS. 15
b) Discuss bioactivation and tissue toxicity.
SECTION – II
5. Explain the factors influencing renal excretion of drug. 10
6. a) Explain the different mechanism of drug interactions. 10
b) Quote examples of beneficial drug interactions. 5
7. What are pharmacokinetic models ? What is the importance and utility of developing
such models ? Discuss briefly the types of pharmacokinetic models. 15
8. a) What is flip-flop phenomenon ? 7.5
b) Discuss the types of physiological models. 7.5
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