Dr. A.P.J. Abdul Kalam University M PHARMACY I SEM (ALL BRANCH) Pharmacological & Toxicological Screening Methods-I (MPL 103T) Dec 2020 Question Paper

Dr. A.P.J. Abdul Kalam University

Master of Pharmacy (Pharmacology)

First Semester Main Examination, Dec-2020

Pharmacological & Toxicological Screening Methods-I (MPL 103T)

Time: 3:00 Hrs Max Marks 75

Note : Attempt any five questions. All questions carry equal marks.

Q.1 (a) Describe the CPCSEA guidelines to conduct experiments on animals.

(b) Discuss the good laboratory practice.

Q.2 (a) Discuss about anti cancer in-vitro and in-vivo screening methods.

(b) What is diabetes Enumerate various screening models for diabetes. Discuss any

one method in details.

Q.3 (a) Discuss the methods involved in CNS stimulants and depressants activities.

(b) What is parkinsonism ? List out the screening models for parkinsonism and

explain MPTP model in details.

Q.4 (a) Discuss about common laboratory animals.

(b) Discuss the anesthesia and euthanasia of experimental animal.

Q.5 (a) Write the preclinical screening method for antiinflammatory and antipyretic

agents.

(b) Discuss the methods involved in screening a compound supposed to have

antiulcer activity.

Q.6 (a) Write the screening methods for anti asthmatic drugs

(b) Enumerate anti fertility screening methods.

Q.7 (a) Brife discussion on general principal of immunoassay and write note on

immunoassay for insulin.

(b) Write note on preclinical screening methods for immunomodulators activity.

Q.8 Write a note on. :-

(a) Screening methods for antidiarrheal drug activity.

(b) Screening methods for antihypertensive activity.

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