Dr.A.P.J.Abdul Kalam University D.PHARMA II YEAR AUG 2020 Pharmacology & Toxicology [DPY-203] Aug-Sep 2020 Question Paper

Dr.A.P.J.Abdul Kalam University Old Question Papers

Diploma in Pharmacy

Second Year Main Examination, Aug-Sep 2020

Pharmacology & Toxicology [DPY-203]

Time: 3:00 Hrs Max Marks 80

Note : Attempt any five questions. Each question carries equal marks.

Q.1 Attempt multiple choice questions- (Any eight)

(xxi) Pharmacokinetics is:

a) The study of biological and therapeutic effects of drugs

b) The study of absorption, distribution, metabolism and excretion of drugs

c) The study of mechanisms of drug action

d) The study of methods of new drug development

(xxii) What does “pharmacokinetics” include?

a) Complications of drug therapy

b) Drug biotransformation in the organism

c) Influence of drugs on metabolism processes

d) Influence of drugs on genes

(xxiii) Tick the second messenger of G-protein-coupled (metabotropic) receptor:

a) Adenylyl cyclase b) Sodium ions

c) Phospholipase C d) cAMP

(xxiv) The primary mechanism of action of local anesthetics is:

a) Activation of ligand-gated potassium channels

b) Blockade of voltage-gated sodium channels

c) Stimulation of voltage-gated N-type calcium channels

d) Blockade the GABA-gated chloride channels

(xxv) Indicate the location of M2 cholinoreceptor type:

a) Heart b) Glands

c) Smooth muscle d) Endothelium

(xxvi) Parasympathomimetic drugs cause:

a) Bronchodilation b) Mydriasis

c) Bradycardia d) Constipation

(xxvii) Which of the following cholinomimetics is used in the treatment of atropine intoxication?

a) Neostigmine b) Carbochol

c) Physostigmine d) Lobeline

(xxviii) Patients complain of dry or “sandy” eyes when receiving large doses of:

a) Atropine b) Hexamethonium

c) Pilocarpine d) Carbachol

(xxix) Indicate an antimuscarinic drug, which is effective in the treatment of mushroom poising:

a) Pralidoxime b) Pilocarpine

c) Homatropine d) Atropine

(xxx) Antimuscarinics are used in the treatment of the following disorders EXCEPT:

a) Motion sickness b) Glaucoma

c) Hyperhidrosis d) Asthma

(xxxi) Which of the following chemical agents are used in the treatment of insomnia?

a) Benzodiazepines b) Imidazopyridines

c) Barbiturates d) All of the above

(xxxii) Select the appropriate consideration for phenytoin:

a) It blocks sodium channels

b) It binds to an allosteric regulatory site on the GABA-BZ receptor and prolongs the openings of the

Cl-channels

c) It effects on Ca2+ currents, reducing the low-threshold (T-type) current d) It inhibits GABAtransaminase, which catalyzes the breakdown of GABA

(xxxiii) Phenytoin is used in the treatment of:

a) Petit mal epilepsy b) Grand mal epilepsy

c) Myoclonic seizures d) All of the above

(xxxiv) Choose the drug which is a H2-receptor antagonist:

a) Omeprazole b) Pirenzepine

c) Carbenoxolone d) Ranitidine

(xxxv) Tick the drug influencing the blood flow which is related to antiplatelet agents:

a) Heparin b) Aspirin

c) Pyracetam d) none of above

(xxxvi) The Immunosuppressive agent is:

a) Corticosteroids b) Cyclosporine

c) Tacrolimus (FK 506) d) All of the above

(xxxvii) Spironolactone (Aldactone) acts at this nephron site:

a) Proximal convoluted tubule

b) Ascending thick limb of the loop of Henle

c) Distal convoluted tubule

d) Collecting duct

(xxxviii)Tick the drug, inhibiting uncoating of the viral RNA:

a) Vidarabine b) Rimantadine

c) Acyclovir d) Didanozine

(xxxix) All of the following groups of drugs are for thrombosis treatment EXCEPT:

a) Anticoagulant drugs b) Antifibrinolitic drugs

c) Fibrinolitic drugs d) Antiplatelet drugs

(xl) The reason of beta-blockers administration for hypertension treatment is:

a) Peripheral vasodilatation

b) Diminishing of blood volume

c) Decreasing of heart work

d) Depression of vasomotor center

Q.2 Write short note on (support with example)

i) Expectorant and antitussive

ii) Drug used in glaucoma

Q.3 Write a short note on (support with classification)

i) NSAIDs

ii) H2Blockers

Q.4 Write a short note (support with MOA)

i) Drug used in peptic ulcer

ii) Oral Contraceptives

Q.5 Write a short note on

i) Use of aspirin in angina

ii) Rational for the addition of clavulanic acid with amoxicillin

Q.6 Classify anti-anginal drug. Discuss mechanism of action, adverse effect and use of Isosorbide.

Q.7 Classify antileprotic drug. Write pharmacological action, adverse effect and

therapeutic uses of Dapsone.

Q.8 Write mechanism of action, adverse effect and use of the following

i) Warfarin

ii) Salbutamol

iii) Valproic acid

 Q.9 Write a note on

i) diuretic drugs

ii) Sulphonamide

iii) Disinfectants & antiseptics

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