Tuesday, December 29, 2015

PHARMACEUTICAL CHEMISTRY – IV MEDICINAL,2010 Question Paper,University Of Pune Question Paper,Third Year B.Pharmacy

University Of Pune Question Paper
Third Year B.Pharmacy Examination, 2010
PHARMACEUTICAL CHEMISTRY – IV (MEDICINAL)
(2004 Course)
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question No. 1 and 5 are compulsory. Out of the remaining
attempt two questions from Section I and two from Section II.
2) Answers to the two Sections should be written in separate
books.
3) Figures to the right indicate full marks.
SECTION – I
1. Write structure, IUPAC name, and mechanism of action of the following any three :
1) Ciprofloxacin
2) Dapsone
3) Metronidazole
4) Clotrimazole. 12
2. A) Discuss the development and SAR for quinolone antibacterial. 7
B) Write the mechanism of action and synthesis of Chlormphenicol. 7
3. A) What is cancer ? Classify anticancer drugs with examples. 7
B) What are antithyroid agents ? Classify with examples. 7
4. A) What are sulphonamides ? Discuss the physicochemical properties and SAR
for sulphonamides. 7
B) Write the synthesis and mode of action for sulphamethoxazole. 7
SECTION – II
5. A) What is tuberculosis ? Add a note on first line agents. 6
B) Write the mode of action, synthesis and metabolism of Isoniazide. 6
6. A) What are antimetabolites ? Classify the chemotherapeutic agents acting as
antimetabolites with examples. 7
B) Explain the chemistry of antimetabolite used as antimalarials. 7
7. A) What is viral infection ? Classify antiviral drugs with examples. 7
B) Write the structure IUPAC name, mode of action and metabolism of acyclovir. 7
8. Write note on any two : 14
1) Chemistry of Tetracyclines
2) Prodrugs
3) Conjugation reactions in drug metabolism.


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