Tuesday, December 29, 2015

PHARMACEUTICAL CHEMISTRY – IV MEDICINAL,2010 Question Paper,University Of Pune Question Paper,Third Year B.Pharmacy

University Of Pune Question Paper
Third Year B.Pharmacy Examination, 2010
(2004 Course)
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question No. 1 and 5 are compulsory. Out of the remaining
attempt two questions from Section I and two from Section II.
2) Answers to the two Sections should be written in separate
3) Figures to the right indicate full marks.
1. Write structure, IUPAC name, and mechanism of action of the following any three :
1) Ciprofloxacin
2) Dapsone
3) Metronidazole
4) Clotrimazole. 12
2. A) Discuss the development and SAR for quinolone antibacterial. 7
B) Write the mechanism of action and synthesis of Chlormphenicol. 7
3. A) What is cancer ? Classify anticancer drugs with examples. 7
B) What are antithyroid agents ? Classify with examples. 7
4. A) What are sulphonamides ? Discuss the physicochemical properties and SAR
for sulphonamides. 7
B) Write the synthesis and mode of action for sulphamethoxazole. 7
5. A) What is tuberculosis ? Add a note on first line agents. 6
B) Write the mode of action, synthesis and metabolism of Isoniazide. 6
6. A) What are antimetabolites ? Classify the chemotherapeutic agents acting as
antimetabolites with examples. 7
B) Explain the chemistry of antimetabolite used as antimalarials. 7
7. A) What is viral infection ? Classify antiviral drugs with examples. 7
B) Write the structure IUPAC name, mode of action and metabolism of acyclovir. 7
8. Write note on any two : 14
1) Chemistry of Tetracyclines
2) Prodrugs
3) Conjugation reactions in drug metabolism.

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