University:West Bengal University of Technology
Course: B.Sc Microbiology
Subject : MOLECULAR HUMAN GENETICS
Year of Question Paper : 2012
CS/B.Sc.(H)/GENETICS/MOL. BIO/SEM-6/MLG-603/2012
2012
MOLECULAR HUMAN GENETICS
Time Allotted : 3 Hours Full Marks : 70
The figures in the margin indicate full marks.
Candidates are required to give their answers in their own words
as far as practicable.
GROUP – A
( Multiple Choice Type Questions )
1. Choose the correct alternatives for any ten of the following :
10 × 1 = 10
i) Who coined the term "Genome" ?
a) Bateson b) Winkler
c) Johansson d) Mendel.
ii) Which Human chromosome is the largest acrocentric
chromosome ?
a) 13 b) 14
c) 15 d) Y.
iii) Which chromosome possesses lowest number/density of
genes ?
a) 13 b) Y
c) 1 d) 22.
iv) Allelic heterogeneity means
a) existence of many different disease-causing alleles
at same locus
b) same disease by mutations at different loci
c) variable expression of a gene in the same locus
d) complex patterns of inheritance occur from thesame locus.
v) In which year Map based Duchene Muscular Dystrophy
Gene was discovered on Chromsome Xp ?
a) 1982 b) 1986
c) 1987 d) 1988.
vi) In which year Human Genome Project was proposed ?
a) 1982 b) 1985
c) 1988 d) 1990.
vii) Diagnosis of ambigous phenotype of a newborn baby is
done by
a) Physical examination b) Genetic test
c) Hormonal test d) Ultrasound.
viii) The presence of both ovarian and testicular tissue in the
same individual is known as
a) Female pseudohermaphroditism
b) True hermaphroditism
c) XY-Female
d) Mixed gonadal dysgenesis
.
ix) Interference of Gene Expression is due to
a) Missense mutation b) Epigenetic silencing
c) Nonsense mutation d) Unequal crossover.
x) In which year Celera Genomics published their draft of
the human genome in the journal Science ?
a) 1999 b) 2001
c) 2002 d) 2003.
xi) In which year Map based Roberts Syndrome Gene was
Discovered on chromosome 13q ?
a) 2000 b) 2005c) 2006 d) 2008.
GROUP – B
( Short Answer Type Questions )
Answer any three of the following. 3 × 5 = 15
2. What are the methods of Gene Mapping ?
3. Define variable gene expression in complex genetic disorder.
4. What is Polygenic Disorder ? Explain with example.
5. What is Epigenetic silencing ? How is it related to Gene
Expression ?
6. How do Unstable Expanding Repeats in coding region affect
in Fragile X Syndrome ?
GROUP – C
( Long Answer Type Questions )
Answer any three of the following. 3 × 15 = 45
7. What is STS ? What are the type STSs available in Human
Genome ? What are the vectors used as a Library in Human
Genome Project ? Describe the Laboratory Protocol used in
Human Genome Project. 2 + 3 + 3 + 7
8. What are Genetic Markers ? What are the types of Genetic
Markers used in Gene Mapping ? What is the molecular
basis of DNA fingerprinting ? Who is the inventor of the same
technology ? 2 + 3 + 8 + 2
9. How do you sequence a whole Genome ? What is cDNA
sequencing ? What is current status of DNA sequencing
technology ? What is Bermuda agreement in HGP ?
10. What is Haplotype ? What is Genomic Variation ? How does
Haplotype help in searching genes in Complex Genetic
Disorders ?11. What is Complex Genetic Disease ? Describe inheritance
pattern in complex genetic disorders. What are the
differences between monogenic and complex genetic
disorders ? 3 + 6 + 6
============..
Course: B.Sc Microbiology
Subject : MOLECULAR HUMAN GENETICS
Year of Question Paper : 2012
CS/B.Sc.(H)/GENETICS/MOL. BIO/SEM-6/MLG-603/2012
2012
MOLECULAR HUMAN GENETICS
Time Allotted : 3 Hours Full Marks : 70
The figures in the margin indicate full marks.
Candidates are required to give their answers in their own words
as far as practicable.
GROUP – A
( Multiple Choice Type Questions )
1. Choose the correct alternatives for any ten of the following :
10 × 1 = 10
i) Who coined the term "Genome" ?
a) Bateson b) Winkler
c) Johansson d) Mendel.
ii) Which Human chromosome is the largest acrocentric
chromosome ?
a) 13 b) 14
c) 15 d) Y.
iii) Which chromosome possesses lowest number/density of
genes ?
a) 13 b) Y
c) 1 d) 22.
iv) Allelic heterogeneity means
a) existence of many different disease-causing alleles
at same locus
b) same disease by mutations at different loci
c) variable expression of a gene in the same locus
d) complex patterns of inheritance occur from thesame locus.
v) In which year Map based Duchene Muscular Dystrophy
Gene was discovered on Chromsome Xp ?
a) 1982 b) 1986
c) 1987 d) 1988.
vi) In which year Human Genome Project was proposed ?
a) 1982 b) 1985
c) 1988 d) 1990.
vii) Diagnosis of ambigous phenotype of a newborn baby is
done by
a) Physical examination b) Genetic test
c) Hormonal test d) Ultrasound.
viii) The presence of both ovarian and testicular tissue in the
same individual is known as
a) Female pseudohermaphroditism
b) True hermaphroditism
c) XY-Female
d) Mixed gonadal dysgenesis
.
ix) Interference of Gene Expression is due to
a) Missense mutation b) Epigenetic silencing
c) Nonsense mutation d) Unequal crossover.
x) In which year Celera Genomics published their draft of
the human genome in the journal Science ?
a) 1999 b) 2001
c) 2002 d) 2003.
xi) In which year Map based Roberts Syndrome Gene was
Discovered on chromosome 13q ?
a) 2000 b) 2005c) 2006 d) 2008.
GROUP – B
( Short Answer Type Questions )
Answer any three of the following. 3 × 5 = 15
2. What are the methods of Gene Mapping ?
3. Define variable gene expression in complex genetic disorder.
4. What is Polygenic Disorder ? Explain with example.
5. What is Epigenetic silencing ? How is it related to Gene
Expression ?
6. How do Unstable Expanding Repeats in coding region affect
in Fragile X Syndrome ?
GROUP – C
( Long Answer Type Questions )
Answer any three of the following. 3 × 15 = 45
7. What is STS ? What are the type STSs available in Human
Genome ? What are the vectors used as a Library in Human
Genome Project ? Describe the Laboratory Protocol used in
Human Genome Project. 2 + 3 + 3 + 7
8. What are Genetic Markers ? What are the types of Genetic
Markers used in Gene Mapping ? What is the molecular
basis of DNA fingerprinting ? Who is the inventor of the same
technology ? 2 + 3 + 8 + 2
9. How do you sequence a whole Genome ? What is cDNA
sequencing ? What is current status of DNA sequencing
technology ? What is Bermuda agreement in HGP ?
10. What is Haplotype ? What is Genomic Variation ? How does
Haplotype help in searching genes in Complex Genetic
Disorders ?11. What is Complex Genetic Disease ? Describe inheritance
pattern in complex genetic disorders. What are the
differences between monogenic and complex genetic
disorders ? 3 + 6 + 6
============..
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