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Friday, January 8, 2016

Paper VI – BIOCHEMISTRY – II,Dr. MGR University Question Paper,FIRST M.B.B.S.,2014 Question Paper

Dr. MGR University Question Paper
Q. P. Code : 524056
Time : 180 Minutes Maximum: 50 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Elaborate on: (2 x 7.5 = 15)
 1. What is the reference range for serum uric acid?
 What is the source of uric acid in the body?
 What is its ultimate fate?
 Discuss causes of abnormalities in levels of serum uric acid.
 2. Describe recombinant DNA technology.
 Explain the different techniques with its application.
II. Write notes on: (10 x 2.5 = 25)
1. Essential amino acids
2. Structure of tRNA
3. Restriction endonucleases
4. Post-translational modifications of proteins
5. What is creatine clearance? Write the normal value of it.
6. Sources of ammonia in the body and its metabolism
7. Functions of glycine in the body
8. Heavy metal poisonings
9. Disorders associated with potassium homeostasis
 10. Functions of nucleotides
III. Short Answers on: (10 x 1 = 10)
1. List two applications of electrophoresis in medicine.
2. List the different types of immunoglobulins.
3. Outline the reaction by which deoxynucleotides are formed in a cell from ribonucleotides.
4. Explain the anti-neoplastic effect of methotrexate.
5. List the biochemical abnormalities seen in phenylketonuria.
6. What are the compensatory changes that occur in response to respiratory acidosis?
7. Outline the mechanism of action of glucagon
8. What is reference range of sodium. Write 2 causes of hyponatremia.
9. What is the function of cytochrome P450 in the body?
 10. Name two tumour suppressor genes and the malignancy that is specifically associated
 with abnormalities in each of these genes.

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