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Friday, January 29, 2016

PAPER III BIOPHARMACEUTICS AND PHARMACOKINETICS Dr. MGR University 2011 to 2015 Question Papers

Dr. MGR University  MAY 2011 Question Paper
Subject : PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS

[KY 342] Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 262903
Time: Three Hours Maximum: 100 marks
 Answer ALL questions
I. Elaborate on : (6 x 10 = 60)
 1. Explain the steps involved in oxidation of xenobiotics.
 2. Describe the in vitro dissolution testing models.
 3. The equation that best fits the plasma level time curve of a drug after an IV bolus
 dose of 500mg is: C=143e-0.87t. Assuming one compartment kinetics calculate
 (a) Vd (b) Cl (c) Half life (d) AUC
 4. What are compartment models?
 Derive an expression for calculating various pharmacokinetic parameters for a drug
 administered by IV bolus administration.
 5. Define Pharmacokinetics.
 Explain the various pharmacokinetic parameters that describes a typical plasma
 Level-time curve.
 6. What are drug interactions?
 Explain the various types of pharmacokinetic drug interactions.
II. Write notes on : (8 x 5 = 40)
 1. What is BCS? On what basis the drugs are classified under BCS?
 2. Give the advantages of urinary excretion data in pharmacokinetic analysis.
 3. Define dose-dependent kinetics. Give some tests to detect the same in a rate process.
 4. Define Persistence factor and Loss factor.
 5. What is the influence of protein binding and displacement interaction on half life of
 a drug?
 6. Briefly explain the components of Mixed function oxidases.
 7. Explain the Latin square cross-over design for bioequivalency study with an example.
 8. Describe briefly the influence of genetic factors in pharmacokinetic variability.
*******

Dr. MGR University OCTOBER  2011 Question Paper
Subject : PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS

[KZ 342] Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 262903
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
 (Max.) (Max.) (Max.)
 1. Explain Non-Linear pharmacokinetics.
 Derive an expression for Michaelis Menten equation. 17 40 min. 20
 2. Explain in detail about the designing and protocol of
 bioequivalence studies. 17 40 min. 20
II. Write notes on :
 1. With a neat diagram and explain G.I membrane. 4 10 min. 6
 2. Explain the significance of plasma protein binding in drug
 distribution and effects. 4 10 min. 6
 3. Explain any one Invitro method for studying drug absorption
 by non-oral route. 4 10 min. 6
 4. Write a note on: 4 10 min. 6
 (i) Blood Brain Barrier
 (ii) Cerebro spinal fluid barrier.
 5. Write a note on therapeutic drug monitoring. 4 10 min. 6
 6. Explain the Pharmacokinetic variability in body weight and age. 4 10 min. 6
 7. Write a note on dosage adjustment in Renal disease. 4 10 min. 6
 8. Explain pH partition hypothesis. 4 10 min. 6
 9. Write a note on passive diffusion of drugs. 4 10 min. 6
10. Explain the following:
 (i) AUMC
 (ii) MRT. 4 10 min. 6
*******

Dr. MGR University  MAY 2012 Question Paper
Subject : PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS

[LA 342] Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 262903
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
 (Max.) (Max.) (Max.)
 1. Explain Excretion of drugs in detail. 17 40 min. 20
 2. Define Pharmacokinetics and Therapeutic index. 17 40 min. 20
 Describe two compartment open model and derive suitable
 equations to assess Pharmacokinetic parameters of two
 compartment open model.
II. Write notes on :
 1. Mechanism of absorption. 4 10 min. 6
 2. Volume of Distribution. 4 10 min. 6
 3. Hydrolytic reactions. 4 10 min. 6
 4. First order Kinetics. 4 10 min. 6
 5. In vitro-in vivo correlation. 4 10 min. 6
 6. Maintenance dose. 4 10 min. 6
 7. Dose adjustment in renal disease. 4 10 min. 6
 8. Formulation factors in absorption. 4 10 min. 6
 9. Subjects for Bioequivalence study. 4 10 min. 6
10. Drug binding in tissues. 4 10 min. 6
*******

Dr. MGR University OCTOBER 2012 Question Paper
Subject : PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS

[LB 342] Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 262903
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
 (Max.) (Max.) (Max.)
 1. Explain Phase I and Phase II biotransformation reactions. 17 40 min. 20
 2. Discuss various physico-chemical and biological factors
 affecting drug absorption in the gastrointestinal tract. 17 40 min. 20
II. Write Notes on :
 1. Passive and active transport of drugs. 4 10 min. 6
 2. Causes of non-linear pharmacokinetics and Michaelis-Menten
 equation. 4 10 min. 6
 3. Factors influencing drug clearance. 4 10 min. 6
 4. Methods of studying drug protein binding. 4 10 min. 6
 5. Volume of distribution and factors affecting it. 4 10 min. 6
 6. Non-compartmental methods of estimating pharmacokinetic
 parameters. 4 10 min. 6
 7. Methods of measurement of bioavailability. 4 10 min. 6
 8. Therapeutic drug monitoring and its significance. 4 10 min. 6
 9. Classification of drug-drug interactions with examples. 4 10 min. 6
10. Any three methods of enhancing bioavailability of poorly
 water soluble drugs. 4 10 min. 6
*******

Dr. MGR University APRIL 2013 Question Paper
Subject : PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS

[LC 342] Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 262903
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. Define Biotransformation of drugs.
 Explain Phase I reactions and the factors affecting Biotransformation.
 2. What is Relative Bioavailability?
 Describe the protocols of Bioequivalence study.
II. Write notes on : (10 x 6 = 60)
 1. Drug related factors in absorption.
 2. Factors affecting distribution of drugs.
 3. Oxidation of Carbon-Nitrogen system.
 4. Non renal excretion.
 5. Wagner-Nelson method.
 6. Glucuronidation.
 7. Drug accumulation.
 8. Dosing of drugs in obese patients.
 9. Topical absorption of drugs.
10. Protein binding.
*******

Dr. MGR University OCTOBER 2013 Question Paper
Subject : PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS

[LD 342] Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 262903
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. Describe the mechanism of drug absorption and Biological factors influencing drug
 absorption.
 2. What is clinical Pharmacokinetics?
 Write a detailed account on individualization of dosage regimen.
II. Write notes on : (10 x 6 = 60)
 1. Kinetics of protein drug binding.
 2. Reductive Reactions.
 3. Entero Hepatic cycling.
 4. Factors contributing to drug interactions.
 5. Wagner Nelsen method.
 6. Bioavailability enhancement through enhancement of Solubility and Dissolution rate.
 7. Therapeutic Drug Monitoring.
 8. Drug food interactions.
 9. Absorption from non-oral routes.
10. Michelis Menten equation.
*******

Dr. MGR University APRIL 2014 Question Paper
Subject : PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS

[LE 342] Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 262903
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. Explain the designing and protocol of bioequivalence studies as per CDSCO guidelines.
 2. Discuss various pharmaceutical dosage form factors and physiological factors affecting
 drug absorption in the gastrointestinal tract.
II. Write notes on : (10 x 6 = 60)
 1. Volume of distribution of drugs.
 2. Methods of drug dosage adjustments in renal impairment.
 3. Phase II biotransformation of drugs.
 4. Pharmacokinetic variability in thyroid disease.
 5. Pharmacokinetic drug interactions.
 6. Area under first moment curve and mean residence time.
 7. Drug penetration to CNS.
 8. Plasma protein binding of drugs.
 9. Concept of loading dose and maintenance dose.
10. Any 6 methods to improve bioavailability of poorly water soluble drugs.
*******

Dr. MGR University OCTOBER 2014 Question Paper
Subject : PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS

[LF 342] Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 262903
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. Define Biotransformation of drugs. Explain phase II reactions.
 2. a) Explain the methods of adjusting the dose and dosage regimen in patients
 with Renal and Hepatic diseases.
 b) Describe Pharmacodynamic parameters.
II. Write notes on : (10 x 6 = 60)
 1. Topical administration of drugs.
 2. Factors affecting distribution of drugs.
 3. Hydrolytic reactions.
 4. Renal excretion of drugs.
 5. Causes of non-linearity.
 6. Invitro invivo correlation.
 7. Dosing of drugs in neonates, infants and children.
 8. Mechanism of drug interactions.
 9. Non compartment method.
10. Volume of distribution.
*******

Dr. MGR University APRIL 2015 Question Paper
Subject : PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS

[LG 342] Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER III – BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 262903
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. a) Write about the biological factors affecting drug absorption.
 b) Mention an In vitro and In vivo method for determining drug absorption.
 2. a) Derive Michaelis Menten equation.
 b) Describe about In Vitro and In vivo correlation method.
II. Write notes on : (10 x 6 = 60)
 1. Differentiate Active and Passive transport.
 2. Write about placental drug distribution.
 3. Explain any two phase II reaction with example.
 4. Describe Non renal excretion.
 5. Explain first order kinetics.
 6. Explain Area under first moment curve and mean residence time.
 7. Specify the CDSCO protocol for bioequivalence study.
 8. Write the concept involved in pharmacokinetic modeling.
 9. Mention the concept behind multiple dosing in oral administration.
10. Describe the dosage adjustment procedure during cardiovascular and liver disorders.
******* 

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