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Friday, January 8, 2016

2012 Question Paper,FIRST M.B.B.S.,Dr. MGR University Question Paper,Paper VI – BIOCHEMISTRY – II,

Dr. MGR University Question Paper
Q. P. Code : 524056
Time : 180 Minutes Maximum: 100 Marks
Answer ALL questions.
Draw Suitable diagrams wherever necessary
I. Elaborate on: Pages Time Marks
 (Max.) (Max.) (Max.)
 1. With the help of a figure, describe the process by which
 DNA replication takes place in a cell. 16 25 15
 2. What are the functions of sodium in the body?
 What is the reference range for levels of serum sodium?
 Describe the working of the renin-angiotensin-aldosterone system
 to maintain optimal amounts of sodium in the body.
 Briefly discuss disorders associated with derangements in
 sodium homeostasis. 16 25 15
II. Write notes on:
1. Secondary structure of proteins. 3 8 5
2. Structure of an immunoglobulin, with the help of a figure. 3 8 5
3. Causes and manifestations of gout. 3 8 5
4. Transamination reactions. 3 8 5
5. Role of lungs in maintenance of pH of blood. 3 8 5
6. Conjugation reactions involved in metabolism of xenobiotics. 3 8 5
7. Principle and applications of electrophoresis. 3 8 5
8. Functions of tyrosine in the body. 3 8 5
9. Tumour markers. 3 8 5
 10. Salvage pathway for purines and its importance in the body. 3 8 5
III. Short Answers on:
 1. Outline the distribution of water in the various compartments
 of the body. 1 5 2
 2. What is the mechanism of action of steroid hormones? 1 5 2
 3. List four features of the genetic code. 1 5 2
 4. Explain the clinical relevance of serum creatinine levels. 1 5 2
 5. What is meant by the polymerase chain reaction?
 List Two of its applications. 1 5 2
 6. What are the reference levels of glucose and protein in
 cerebrospinal fluid?
 How are they affected in bacterial meningitis? 1 5 2
 7. What is meant by quartenary structure of a protein?
 Name a protein, abundantly found in blood that has a quartenary
 structure. 1 5 2
 8. Name the bases found in nucleic acids. 1 5 2
 9. List four causes of respiratory acidosis. 1 5 2
 10. What are the functions of glutathione? 1 5 2

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