Monday, December 28, 2015

Fourth Year B.Pharmacy,University Of Pune Question Paper,2010 Question Paper,PHARMACEUTICAL CHEMISTRY V (Medicinal)

University Of Pune Question Paper
Fourth Year B.Pharmacy Examination, 2010
PHARMACEUTICAL CHEMISTRY V (Medicinal)
(2004 – Course)
Time : 3 Hours Max. Marks : 80
 Note : 1) Q.No. 1 and Q.No. 5 are compulsory. Out of remaining
attempt two questions from Section I and two questions from
Section II.
2) Answer to the two Sections should be written in separate
answer books.
3) Figures to the right indicate full marks.
4) Correct structure must be drawn wherever necessary.
SECTION – I
1. Classify CNS depressants and add a note on SAR, MOA of benzodizepins. 12
2. a) What are major pathways of metabolism ? Explain phase II reactions using
suitable examples. 6
b) Explain adrenergic receptors and add a note on 1
-selective blockers. 6
c) Draw synthesis of atenolol. 2
3. a) Classify general anasthetics and add a note on SAR of barbiturates. 6
b) Write a note on MAO inhibitors. 6
c) Draw synthesis of Phenytoin. 2
4. a) Write notes on (any three) : 12
1) Drug receptor interactions.
2) Oxazolidinediones as anticonvulsants.
3) Drugs used in Alzeimers disease.
4) Long acting neuroleptics.
b) What are different factors affecting the metabolism ? 2
SECTION – II
5. Classify NSAIDs in detail and write SAR, MOA of salicylates. 12
6. a) Classify antianginal agents and add a note on calcium channel blockers. 6
b) What are thiazide diuretics ? Explain in detail. 6
c) Draw synthesis of diclofenac. 2
7. a) What are opioid analgesics ? Write SAR and MOA of Morphine. 6
b) Write a note on non steroidal estrogenic agents. 6
c) Draw synthesis of omeprazole. 2
8. a) Write notes on (any three) : 12
1) ACE inhibitors
2) Amide based local anesthetics
3) H2 Blockers
4) Class IA antiarrythmic drugs.
b) Draw synthesis of Chorpheniramine or Benzocaine. 2
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