Final Year B.Pharmacy Examination, 2013
4.4 : PHARMACEUTICAL ANALYSIS – III
(2008 Pattern)
Time : 3 Hours Max. Marks : 80
N.B. : 1) Write answer to Section I and Section II in separate books.
2) Q. No. 1 and Q. No. 5 are compulsory.
3) Write two questions from Section I and two questions from
Section II from the remaining.
SECTION – I
1. Answer any five of the following. Two marks each.
A) Why trans-1, 2-dichloroethene is IR inactive ?
B) How many NMR signals are shown by the following compounds ?
1) Ethoxy acetic acid
2) Diethyl ether
3) Tert-butyl amine
4) Acetone
C) In GLC, how the flow rate of carrier gas is controlled and measured ? How the
soap-bubble flow meter works ?
D) What is ortho effect in mass spectrometry ? Explain with example.
E) What is full name of WCOT, SCOT and FSCOT columns used in Gas
chromatography ?
F) Which of the following diatomic molecules do not absorbs in Infrared region ?
1) HCl
2) HBr
3) N2
4) H2
5) O2
Seat
No.
P.T.O.
[4355] – 404 -2-
2. A) Explain the principle, instrumentation and applications of Flash
chromatography. 8
B) Explain the principle of the capillary Zone electrophoresis. 7
3. A) Discuss the types of IR transducers. 8
B) Explain the basic principle of IR spectroscopy. 7
4. Write note on (any three) : 15
1) Factors affecting chemical shift
2) Validation of analytical method as per ICH guidelines
3) HETP
4) Van Dee meter equation
SECTION – II
5. A) Explain in brief Trouble shooting and degassing techniques in HPLC. 5
B) How PH affects the separation of amino acids by electrophoresis ? Explain. 5
6. A) Explain the McLafferty rearrangement with suitable example. 8
B) Write the principle and instrumentation of Mass spectrometer. 7
7. A) Explain the theory of Nuclear Magnetic Resonance spectroscopy. 8
B) How will you differentiate Salicylic acid and m-Hydroxy benzoic acid by IR
Spectra ? 7
8. Write note on (any three) : 15
1) Polymorphism
2) HID calculations
3) Columns used in Gas chromatography
4) Supercritical fluid extraction
–––––––––––––––––
B/I
4.4 : PHARMACEUTICAL ANALYSIS – III
(2008 Pattern)
Time : 3 Hours Max. Marks : 80
N.B. : 1) Write answer to Section I and Section II in separate books.
2) Q. No. 1 and Q. No. 5 are compulsory.
3) Write two questions from Section I and two questions from
Section II from the remaining.
1. Answer any five of the following. Two marks each.
A) Why trans-1, 2-dichloroethene is IR inactive ?
B) How many NMR signals are shown by the following compounds ?
1) Ethoxy acetic acid
2) Diethyl ether
3) Tert-butyl amine
4) Acetone
C) In GLC, how the flow rate of carrier gas is controlled and measured ? How the
soap-bubble flow meter works ?
D) What is ortho effect in mass spectrometry ? Explain with example.
E) What is full name of WCOT, SCOT and FSCOT columns used in Gas
chromatography ?
F) Which of the following diatomic molecules do not absorbs in Infrared region ?
1) HCl
2) HBr
3) N2
4) H2
5) O2
Seat
No.
P.T.O.
[4355] – 404 -2-
2. A) Explain the principle, instrumentation and applications of Flash
chromatography. 8
B) Explain the principle of the capillary Zone electrophoresis. 7
3. A) Discuss the types of IR transducers. 8
B) Explain the basic principle of IR spectroscopy. 7
4. Write note on (any three) : 15
1) Factors affecting chemical shift
2) Validation of analytical method as per ICH guidelines
3) HETP
4) Van Dee meter equation
SECTION – II
5. A) Explain in brief Trouble shooting and degassing techniques in HPLC. 5
B) How PH affects the separation of amino acids by electrophoresis ? Explain. 5
6. A) Explain the McLafferty rearrangement with suitable example. 8
B) Write the principle and instrumentation of Mass spectrometer. 7
7. A) Explain the theory of Nuclear Magnetic Resonance spectroscopy. 8
B) How will you differentiate Salicylic acid and m-Hydroxy benzoic acid by IR
Spectra ? 7
8. Write note on (any three) : 15
1) Polymorphism
2) HID calculations
3) Columns used in Gas chromatography
4) Supercritical fluid extraction
–––––––––––––––––
B/I
0 comments:
Pen down your valuable important comments below