Dr. A.P.J. Abdul Kalam University M PHARMACY I SEM (ALL BRANCH) Modern Pharmaceutical Analytical Techniques (MQA-101T) Dec 2020 Question Paper

Dr. A.P.J. Abdul Kalam University

Master of Pharmacy (Quality Assurance)

First Semester Main Examination, Dec-2020

Modern Pharmaceutical Analytical Techniques (MQA-101T)

Time: 3:00 Hrs Max Marks 75

Note : Attempt any five questions. All questions carry equal marks.

Q.1 (a) Describe the principle of UV Spectrophotometers and discuss double beam

Spectrophotometer with neat diagram.

(b) Define fluorescence. Explain the principle & instrumentation of

specetroflourimetry.

Q.2 (a) Discuss various ionization techniques used in mass Spectroscopy.

(b) Explain the terms:

i) Chemical Shift ii) Spin-Spin Coupling

Q.3 (a) Explain the fragmentation rules of organic compounds by mass

spectroscopy in details.

(b) Write a note on 13C NMR.

Q.4 (a) Discuss the principle, instrumentation and application of FTIR.

(b) Discuss the principle, instrumentation and application of Flame Emission

Spectroscopy.

Q.5 (a) Write a brief account on TGA.

(b) Discuss the principle, instrumentation and application of gel

electrophoresis.

Q.6 (a) Write an account on Bragg’s Law and x-ray powder diffraction.

(b) Explain the principle of high performance liquid chromatography. Write an

account on detectors used in HPLC.

Q.7 (a) Discuss the various modes of molecular vibrations. Explain the factors

affecting vibrational frequencies of IR Spectroscopy.

(b) Write a short note on Mclafferty rearrangement and its significance in

structural diagnosis.

Q.8 (a) Discuss principle of gas chromatography and explain any two detectors used

in it.

(b) Explain the principle, working and instrumentation of potentiometers.

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