Wednesday, February 8, 2023

Dr. A.P.J. Abdul Kalam University M.Pharm (Pharmacology) II Sem Pharmacological and Toxicological Screening Methods- II [MPL202T] June 2021 Question Paper

Dr. A.P.J. Abdul Kalam University

Master of Pharmacy (Pharmacology)

Second Semester Examination, June-2021

Pharmacological and Toxicological Screening Methods- II [MPL202T]

Time: 3:00 Hrs Max Marks 75

Note: Attempt any five questions. All questions carry equal marks.

Q.1 (a) Write define and detail types of toxicology.

(b) Write regulatory guidelines for conducting toxicity studies OECD.

Q.2 (a) Write regulatory guidelines for conducting toxicity studies Schedule Y.

(b) Write the principles of good laboratory practice (GLP)

Q.3 (a) Describe an importance and applications of toxic kinetic studies.

(b) Write a note on Ames Test and HERG assay.

Q.4 (a) Describe in detail the in vivo carcinogenicity studies.

(b) Write the history, concept and importance of GLP in drug development .

Q.5 (a) Highlight the acute eye irritation, skin sensitization, dermal irritation &

dermal toxicity studies as per OECD.

(b) Write down the female reproductive toxicology (segment I and segment III) studies.

Q.6 (a) Write down the details of Genotoxicity studies.

(b) Write a note on In vitro and in vivo Micronucleus .

Q.7 (a) Write down the definition and importance of IND.

(b) Write down the origin, concepts and importance of safety pharmacology.

Q.8 (a) Describe in detail the Toxic kinetic evaluation in preclinical studies.

(b) Write a note on Tier-1-CVS, CNS and respiratory safety pharmacology.

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