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Thursday, January 28, 2016

PAPER IV PHARMACEUTICAL ORGANIC CHEMISTRY Dr. MGR University 2009 to 2015 Question Papers

Dr. MGR University SEPTEMBER 2009 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[KV 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(Regulations 2008-2009 )
(Candidates admitted from 2008-2009 onwards)
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on: (2 x 20 = 40)
 1. a) Explain the nucleophilic substitution reactions with suitable examples.
 b) Add a note on mechanisms and kinetics involved in SN¹ and SN² reactions.
 2. Explain the mechanisms of following name reactions.
 a) Benzoin condensation.
 b) Wittig reaction.
 c) Cannizaro reaction.
 d) Kolh’s reaction.
II. Write notes on: (6 x 5 = 30)
 1. Preparation, tests for purity, assay and uses of aspirin.
 2. Explain the reaction mechanisms of sandmeyer’s reduction with suitable examples.
 3. Explain the bimolecular displacement mechanism for nucleophilic aromatic
 substitution with suitable examples.
 4. Explain the conversion of acid to acid chloride and aid to esters with suitable examples.
 5. Describe the effect of substituent groups on aromatic nucleus.
 6. Outline any two methods of preparation of ketones.
*******

Dr. MGR University MARCH 2010 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[KW 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(Regulations 2008-2009 )
(Candidates admitted from 2008-2009 onwards)
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on: (2 x 20 = 40)
 1. Explain the preparation of alcohol with special reference to gniguard synthesis,
 reduction of carbonyl compounds, acids and esters.
 2. Explain the mechanisms of following name reactions.
 a) Claisen condensation.
 b) Knorvenagel reaction.
 c) Michael addition.
 d) Perkin condensation.
II. Write notes on: (6 x 5 = 30)
 1. Explain fries rearrangement and hofmann rearrangement.
 2. Preparation, tests for purity, assay and uses of methyl salicylate.
 3. Explain the diazotization and coupling reactions of amioes.
 4. Explain the 1,2 addition and 1,4 addition reactions of conjugated dienes.
 5. Outline the important chemical properties of aldehydes.
 6. What are cycloalkanes? Give egs. How the cycloalkanes are prepared?
*******

Dr. MGR University SEPTEMBER 2010 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[KX 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(Regulations 2008-2009 )
(Candidates admitted from 2008-2009 onwards)
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on: (2 x 20 = 40)
 1. a) Write the Mechanism, reactivity, orientation of aromatic electrophilic
 substitution reaction with suitable examples.
 b) Explain briefly about hybridization.
 2. a) Why are aldehydes more reactive than ketone?
 Give an account of the nucleophilic additions of aldehyde with the help of general
 mechanism.
 b) What are Organometallic compounds?
 How they are prepared?
 Give its synthetic applications.
II. Write notes on: (6 x 5 = 30)
 1. Give the general methods of preparations of alcohols with examples?
 How will you differentiate between 1º, 2º, 3º alcohols?
 2. Explain the following reactions:
 i) Cannizaro reaction.
 ii) Diel’s Alder reaction.
 3. Give the preparations of Ethers by Williamson’s synthesis.
 4. Add a note on Isomerism.
 5. Explain Bayer’s Strain Theory.
 6. Add a note on Free Radicals.
*******

Dr. MGR University MAY 2011 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[KY 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(Regulations 2008-2009 )
(Candidates admitted from 2008-2009 onwards)
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on: (2 x 20 = 40)
 1. Describe the two mechanisms of aliphatic nucleophilic substitution reactions.
 Compare and contrast these two reactions in detail.
 2. Describe in detail free radical halogenation of methane explaining the thermodynamics
 of the reaction with respect to the halogens: F, Cl, Br, & I.
II. Write notes on: (6 x 5 = 30)
 1. Preparation, tests for purity, assay, and uses of Aspirin.
 2. Aldol condensation and cyanohydrin reaction of aldehydes.
 3. Explain Sandmeyer’s reaction with suitable examples.
 4. Two methods of preparations of aldehydes.
 5. Explain Schotten-Bauman reaction.
 6. Write a note on the advantages of Friedal Crafts Acylation over Alkylation.
*******

Dr. MGR University OCTOBER 2011 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[KZ 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
 (Max.) (Max.) (Max.)
 1. a) Define Electrophilic aromatic substitution reaction.
 Explain the mechanism of nitration, sulphonation, 17 40 min. 20
 halogenation and Friedel craft’s alkylation reactions
 with examples.
 b) Write a note on activating and deactivating O, P, and
 M directing groups.
 2. a) Compare aliphatic nucleophilic bimolecular and
 unimolecular reaction. (SN2 vs SN1). 17 40 min. 20
 b) Explain the mechanism and kinetics of 1, 2
 Elimination reactions. (E2 and E1).
II. Write notes on :
 1. Write a note on Markownikoff’s rule and Peroxide effect. 4 10 min. 6
 2. Explain about electrophilic addition of conjugated dienes. 4 10 min. 6
 (1, 2 versus 1, 4 addition).
 3. Write about the mechanism of Cannizaro’s reaction withexample. 4 10 min. 6
 4. Define polarity of molecules and intermolecular forces with
 examples. 4 10 min. 6
 5. Explain Bayer’s strain theory with its merits and limitations. 4 10 min. 6
 6. Explain Kolbe’s reaction and Reimer -Tiemann’s reaction. 4 10 min. 6
 7. Write a note on allyl radical as a resonance hybrid. 4 10 min. 6
 8. Write a note on oxidation-reduction reactions with examples. 4 10 min. 6
 9. Give an example for free radical halogenation of alkenes with
 respect to carbon – carbon double bond acting as substituent. 4 10 min. 6
10. Define orientation, reactivity and stability. 4 10 min. 6
*******

Dr. MGR University APRIL 2012 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[LA 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
 (Max.) (Max.) (Max.)
 1. a) Elaborate the mechanism , kinetic and stereochemistry
 of aliphatic nucleophilic Substitution (SN1 and SN2
) reaction.
 b) Explain about the role of phase transfer catalysis in
 substitution reaction. 17 40 min. 20
 2. a) Illustrate about the Kinetic, mechanism and isotopic
 effect of E1and E2 reactions.
 b) Add a note on dehydration of acid catalysis. 17 40 min. 20
II. Write notes on :
 1. Give an account of acid and base on the basis of Lewis theories. 4 10 min. 6
 2. Preparation, test for purity, assay and uses of vanillin. 4 10 min. 6
 3. Explain the mechanism of halogenations of alkanes.
 Give the evidence for the same. 4 10 min. 6
 4. Outline any two methods of conversion of acids to acid
 chloride and amide. 4 10 min. 6
 5. Discuss the mechanism and synthetic uses of benzoin
 condensation reaction. 4 10 min. 6
 6. Describe the preparation methods for esters. 4 10 min. 6
 7. Outline briefly about Bayer strain theory. 4 10 min. 6
 8. Discuss the mechanism and synthetic uses of witting reaction. 4 10 min. 6
 9. Write a note on Diels alder reaction. 4 10 min. 6
10. Preparation, test for purity, assay and uses of Aspirin. 4 10 min. 6

 *******

Dr. MGR University OCTOBER 2012 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[LB 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
 (Max.) (Max.) (Max.)
 1. Explain the mechanism of Nucleophilic aromatic substitution
 reactions, orientation and reactivity of benzene. 17 40 min. 20
 2. Give the reactions of alkenes. 17 40 min. 20
II. Write notes on :
 1. Phase transfer catalysis. 4 10 min. 6
 2. SN1 vs. SN2. 4 10 min. 6
 3. Write the preparation of alkyl halides. 4 10 min. 6
 4. Fries rearrangement. 4 10 min. 6
 5. Give the addition reactions of conjugated dienes. 4 10 min. 6
 6. Reformatsky reaction. 4 10 min. 6
 7. Explain peroxide effect. 4 10 min. 6
 8. 4n+2 rule. 4 10 min. 6
 9. Sandmeyer reaction. 4 10 min. 6
10. Write the preparations of Carboxylic acids . 4 10 min. 6
*******

Dr. MGR University APRIL 2013 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[LC 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
 PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 100 marks
 Answer All questions
I. Elaborate on: (2 x 20 = 40)
 1. a) Define elimination reaction.
 Explain about its Kinetic, mechanism and isotopic effect of E1and E2 reactions.
 b) Add a note on dehydration of acid catalysis.
 2. a) Write the Mechanism, reactivity, orientation of aromatic electrophilic substitution
 reaction with suitable examples.
 b) Explain about the resonance stabilization of benzyl radical.
II. Write notes on: (10 x 6 = 60)
 1. Preparation, test for purity, assay and uses of methyl salicylate.
 2. Explain about preparation methods of free radicals.
 3. Outline briefly about Bayer strain theory.
 4. Discuss the mechanism and synthetic uses of Hoffman rearrangement reaction.
 5. Describe the preparation methods for amide.
 6. Preparation, test for purity, assay and uses of Chlorbutol.
 7. Write notes on Inter molecular forces.
 8. Give the mechanism for nitration and sulphonation reaction.
 9. Explain the preparation methods and synthetic uses of diazonium salts.
10. Discuss the mechanism and synthetic uses of Reformatsky reaction.
*******

Dr. MGR University OCTOBER 2013 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[LD 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 70 marks
 Answer All questions
I. Elaborate on: (2 x 20 = 40)
 1. a) Write the Electrophilic addition reactions of alkenes.
 b) Write about basicity of amines.
 2. a) Explain the mechanisms involved in Elimination reactions.
 b) (i) Aldol Condensation.
 (ii) Hoffmann rearrangement.
II. Write notes on: (10 x 3 = 30)
 1. Aliphatic Nucleophilic substitution V.s. Aromatic nucleophilic substitution.
 2. Fries rearrangement.
 3. Write the preparation and medicinal uses of
 a) Vanillin.
 b) Salicylic acid.
 4. Write any three methods of preparation of carboxylic acids.
 5. a) Williamsons synthesis.
 b) Sandmeyer reaction.
 6. 1, 4-addition and. 1,2-addition reactions of Dienes.
 7. Markownikoff’s rule.
 8. Bayers strain theory.
 9. SN1 VS. SN2.
10. Phase transfer catalysis.
*******

Dr. MGR University APRIL 2014 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[LE 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 70 marks
 Answer All questions
I. Elaborate on: (2 x 20 = 40)
 1. What are Electrophilic addition reactions? Explain any two reactions in detail.
 2. Explain the mechanism and reactions of the following:
 a) Claisen condensation.
 b) Knoevenagel reaction.
 c) Perkin condensation.
 d) Kolbe reaction.
II. Write notes on: (10 x 3 = 30)
 1. Diel’s alder reaction.
 2. Discuss the mechanism and synthetic uses of Aldol condensation.
 3. Give an account of acid and base on the basis of Lewis theory.
 4. Give an example for free radical halogenation of alkenes with respect to
 carbon-carbon double bond acting as a substituent.
 5. Write a note on activating and deactivating Ortho, Para and Meta directing groups.
 6. Write any two methods of conversion of acid to esters.
 7. Riemer –Tiemann’s reaction.
 8. Write any two methods to prepare alkyl halides.
 9. Add a note on carbocations.
10. Write the preparation, test for purity, Assay and uses of Saccharin.
*******

Dr. MGR University OCTOBER 2014 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[LF 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(2009-2010 Regulation)
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 70 marks
 Answer All questions
I. Elaborate on: (4 x 10 = 40)
 1. Discuss the reaction, mechanism of Nucleophilic aromatic substitution.
 2. Briefly discuss Stereochemistry of SN1 and SN2 reaction.
 How rearrangement take place in carbocation in Nuclophilic aliphatic substitution.
 3. Mention the reaction of conversion of acid to:
 a) Amide.
 b) Acid chloride.
 c) Esters.
 d) Anhydride.
 4. Explain the following reaction with mechanism:
 a) Diazotisation and coupling.
 b) Aldol condensation.
II. Write notes on: (6 x 5 = 30)
 1. Explain the addition reaction of conjugated dienes.
 2. Write the structure, preparation, Assay and chemical uses of Sodium lauryl sulphate.
 3. Explain the Wittig reaction with mechanisms.
 4. Additions of carbine.
 5. Orbital picture of Allyl radical.
 6. Explain the mechanism of E1 and E2 reaction.
*******

Dr. MGR University APRIL 2015 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[LG 804] Sub. Code: 3804
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(2009-2010 Regulation)
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code: 383804
Time: Three Hours Maximum: 70 marks
 Answer All questions
I. Elaborate on: (4 x 10 = 40)
 1. Discuss the electrophilic substitution reaction in aromatic system.
 Explain Mechanism of their reaction.
 2. Briefly discuss Markownikoff’s rule and Peroxide effect with an example.
 3. Discuss about Dehydro halogenation of alkyl halides.
 Explain about its Kinetic and mechanism of E1and E2 reactions.
 4. Explain the following reaction with mechanism:
 a) Michael addition.
 b) Reimer tieman’s reactions.
II. Write notes on: (6 x 5 = 30)
 1. Write short notes on Baeyr’s strain theory.
 2. Mention the structure and name them according to IUPAC
 i) Formic acid.
 ii) Acetaldehyde.
 iii) Acetamide.
 iv) Neopentane.
 3. Write the structure, preparation, Assay & chemical uses of Ethylene diamine dihyrate.
 4. Explain stereochemistry of SN1 and SN2 reactions.
 5. Explain the method of preparation of esters and anhydride.
 6. Explain the Wittig reaction with mechanisms.
*******

Dr. MGR University OCTOBER 2015 Question Paper
Subject : PAPER IV  PHARMACEUTICAL ORGANIC CHEMISTRY

[LH 804] Sub. Code: 3804
PHARM. D DEGREE EXAMINATION
(2009-2010 Regulation)
FIRST YEAR
PAPER IV – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code : 383804
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on : (4 x 10 = 40)
 1. Write the electrophilic addition reactions of alkenes.
 2. Explain the reactivity and orientation in Electrophilic aromatic substitution with
 activating and deactivating O, P, and M directing groups.
 3. Give the mechanism involved in Aldol condensation and Hoffmann rearrangement.
 4. Explain SN1 reaction with reference to mechanism, kinetics and stereochemistry.
II. Write notes on : (6 x 5 = 30)
 1. Protic and Aprotic solvents.
 2. Phase transfer catalysis.
 3. 1, 2 elimination reactions.
 4. Allylic rearrangement.
 5. Write the preparation and medicinal uses of
 (a) Sodium lauryl sulphate.
 (b) Methyl salicylate.
 6. E2 vs. E1.
******* 

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