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Friday, January 29, 2016

PAPER II ADVANCED ORGANIC CHEMISTRY Dr. MGR University 2011 to 2015 Question Papers

Dr. MGR University MAY 2011 Question Paper
Subject : PAPER II – ADVANCED ORGANIC CHEMISTRY

[KY 344] Sub. Code: 2905
M.PHARM. DEGREE EXAMINATION
(Regulations 2010)
(For candidates admitted from 2010-2011 onwards)
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER II – ADVANCED ORGANIC CHEMISTRY
Q.P. Code : 262905
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (6 x 10 = 60)
 1. Explain localized and delocalized bonds with examples. Dipole moment applications.
 2. Discuss briefly the different synthetic methodologies for obtaining drugs.
 3. Discuss the structure stability and stereochemistry of free radicals.
 4. Discuss in brief for attaching six member heterocyclic ring systems to drugs.
 5. Define anchiomeric assistance by giving two examples define oxidation and reduction
 write about various oxidizing and reducing agents used in oxidation and reduction
 reaction.
 6. Explain orientation and reactivity of Aromatic electrophlic substitution in mono and
 di-substituted benzene.
II. Write notes on : (8 x 5 = 40)
 1. Explain the techniques used to prepare chiral drugs.
 2. Explain hyper conjugation and Inductive effect.
 3. Describe the mechanism of SN1 and SN2 reactions in the case of alkyl halides.
 What is the order of reactivity of primary, secondary and tertiary halides in relation
 to SN1 and SN2 reaction? What factors determine this activity?
 4. Discuss the free radical mechanism for the chlorination of methane.
 5. Discuss Pinacol-Pinacolone rearrangement.
 6. State orbital symmetry rules and their application.
 7. Discuss protection and de protection of different groups.
 8. Discuss nano chemistry in pharmaceutical field.
*******

Dr. MGR University OCTOBER 2011 Question Paper
Subject : PAPER II – ADVANCED ORGANIC CHEMISTRY

[KZ 344] Sub. Code: 2905
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER II – ADVANCED ORGANIC CHEMISTRY
Q.P. Code : 262905
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
 1. a) Define reduction and write about various reducing
 agents used in reduction reactions. 17 40 min. 20
 b) Discuss the phase transfer catalysis and its applications in
 reduction reaction.
 c) Outline the mechanism and discuss the synthetic
 importance of Birch and Meerwin-Pondroff’s reductions.
 2. a) Discuss the stability and structure of free radicals. 17 40 min. 20
 b) Discuss the mechanisms of free radical addition and
 free radical substitution reactions with examples.
II. Write notes on :
 1. Describe the synthetic approaches for attaching heterocyclic
 ring systems in drug molecules having five membered ring systems. 4 10 min. 6
 2. Demonstrate the mechanisms of both acid and base-catalysis
 of tautomerisation. 4 10 min. 6
 3. Discuss protection and de protection of different groups. 4 10 min. 6
 4. Explain the mechanism and application of Reformatsky reaction. 4 10 min. 6
 5. Explain the mechanism of aromatic electrophilic substitution
 reactions. 4 10 min. 6
 6. Define chirality and discuss the importance of chiral drugs. 4 10 min. 6
 7. Write the basic theory of photochemical reactions and
 mention their applications. 4 10 min. 6
 8. Give an account on combinatorial chemistry. 4 10 min. 6
 9. Explain in detail about retrosynthetic analysis. 4 10 min. 6
10. Explain with examples various types of pericyclic reactions. 4 10 min. 6
*******

Dr. MGR University MAY 2012 Question Paper
Subject : PAPER II – ADVANCED ORGANIC CHEMISTRY

[LA 344] Sub. Code: 2905
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER II – ADVANCED ORGANIC CHEMISTRY
Q.P. Code : 262905
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
 1. a) What are reaction intermediates?
 Explain the reaction mechanisms involving any two of them. 17 40 min. 20
 b) Write a note on Retro synthetic analysis.
 2. a) What is elimination reaction?
 Explain the mechanisms of E1 Reaction? 17 40 min. 20
 b) Enumerate the Stereo chemical aspects of SN1, SN2 reaction.
II. Write notes on:
 1. Hoffman rearrangement reaction. 4 10 min. 6
 2. Oppenauer oxidation. 4 10 min. 6
 3. Application of photochemical reaction. 4 10 min. 6
 4. Catalyst involved in reduction reaction. 4 10 min. 6
 5. Disconnection approach. 4 10 min. 6
 6. Chemistry of phenothiazine. 4 10 min. 6
 7. Importance of chiral in the synthesis of medicinal compounds. 4 10 min. 6
 8. Bifunctional components. 4 10 min. 6
 9. Synthesis of indole. 4 10 min. 6
10. Electro cyclic reaction. 4 10 min. 6
*******

Dr. MGR University OCTOBER 2012 Question Paper
Subject : PAPER II – ADVANCED ORGANIC CHEMISTRY

[LB 344] Sub. Code: 2905
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER II – ADVANCED ORGANIC CHEMISTRY
Q.P. Code : 262905
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
 1. a) Explain the mechanism and reactions of addition to carbon
 to hetero multiple bond. 17 40 min. 20
 b) Write a note on the localized and delocalized chemical bonding.
 2. Define oxidation and reduction and discuss about various oxidizing
 and reducing agents used in the oxidation & reduction reaction. 17 40 min. 20
II. Write Notes on :
 1. Discuss the inductive effect and electromeric effect. 4 10 min. 6
 2. What is combinatorial chemistry. Explain it.
 How it is useful in drug discovery. 4 10 min. 6
 3. Describe the homocyclic and heterocyclic bond fission. 4 10 min. 6
 4. Explain the importance of chiral synthesis. 4 10 min. 6
 5. Discuss the principles of micro beads in new solid phase synthesis. 4 10 min. 6
 6. Describe the basicity of pyridine. 4 10 min. 6
 7. Give any three reaction of furan and phenothiazine. 4 10 min. 6
 8. Discuss the stability of free radicals. 4 10 min. 6
 9. Describe the mechanism of Hoffmann’s rearrangement reaction. 4 10 min. 6
10. Give the synthetic application of grignard reagent. 4 10 min. 6
 *******

Dr. MGR University APRIL 2013 Question Paper
Subject : PAPER II – ADVANCED ORGANIC CHEMISTRY

[LC 344] Sub. Code: 2905
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER II – ADVANCED ORGANIC CHEMISTRY
Q.P. Code : 262905
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. Define nucleophilic substitution reaction with examples.
 Explain with examples the mechanism involved in SN1 reaction.
 Enumerate some synthetic reaction involving the nucleophilic substitution reaction.
 2. a) What is aromatic electrophilic substitution reaction?
 Explain with examples the mechanism of them.
 b) Write the mechanism and the application of reformatsky reaction.
II. Write notes on : (10 x 6 = 60)
 1. Asymmetric synthesis.
 2. Theory of acids and basis.
 3. Carbenes and nitrenes.
 4. Deprotection of various groups.
 5. Catalyst involved in hydrolysis.
 6. Orbital symmetry rule.
 7. Pericyclic reaction.
 8. Free radicals.
 9. Reaction of imidazole.
10. Localized and Delocalized chemical bond.
*******

Dr. MGR University OCTOBER 2013 Question Paper
Subject : PAPER II – ADVANCED ORGANIC CHEMISTRY

[LD 344] Sub. Code: 2905
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER II – ADVANCED ORGANIC CHEMISTRY
Q.P. Code : 262905
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. a) Explain in detail the mechanism of Reformatsky reaction
 b) Describe the importance of Chiral drugs giving examples.
 2. a) Classify heterocyclic compounds giving examples.
 Write the preparations, properties of a fused ring structure containing a hetero atom.
 b) Describe the methods for the Deprotection of carboxyl groups.
II. Write notes on : (10 x 6 = 60)
 1. Carbenes.
 2. Mechanism of Michal Reaction.
 3. Nanochemistry.
 4. Carbon to Nitrogen multiple bond.
 5. Catalysts used in reduction reaction.
 6. Protection of amino groups and carboxyl groups.
 7. Free radical mechanism.
 8. Delocalisation.
 9. Theory of Acid and bases.
10. Retrosynthetic analysis.
*******

Dr. MGR University APRIL 2014 Question Paper
Subject : PAPER II – ADVANCED ORGANIC CHEMISTRY

[LE 344] Sub. Code: 2905
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER II – ADVANCED ORGANIC CHEMISTRY
Q.P. Code : 262905
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. a) Explain in detail about the various types of pericyclic reactions and their mechanism.
 b) What do you mean rearrangement reaction? Classify them.
 Explain the different steps involved in it.
 2. a) Discuss on combinatorial chemistry with special reference to its application
 in drug discovery.
 b) Write a note on aliphatic nucleophilic substitution.
II. Write notes on : (10 x 6 = 60)
 1. Mechanism of Walden inversion.
 2. Orbital symmetry rules and its applications.
 3. Oppenauer oxidation.
 4. Theory of Photochemical reactions.
 5. Mechanism and applications of Ozonolysis.
 6. ‘Cotton effect’ and ‘Octant rule’.
 7. Synthesis of Phenothiazine and Purine.
 8. Steps involved in Free radical reactions
 9. Chemical bonding.
10. Techniques for preparing chiral drugs.
*******

Dr. MGR University OCTOBER 2014 Question Paper
Subject : PAPER II – ADVANCED ORGANIC CHEMISTRY

[LF 344] Sub. Code: 2905
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER II – ADVANCED ORGANIC CHEMISTRY
Q.P. Code : 262905
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. Write in detailed account of the Stereochemistry of five membered, six membered
 and fused ring systems.
 2. a) Distinguish the features of E1 and E2 elimination reactions.
 b) Explain the techniques for the preparation of chiral drugs.
II. Write notes on : (10 x 6 = 60)
 1. Neighboring group effect with suitable examples.
 2. Hoffman rearrangement.
 3. Importance of Stereo selective synthesis.
 4. Nucleophilic substitution reactions of pyridine.
 5. Importance of Michael reaction.
 6. Different types of pericyclic reactions with examples.
 7. Ozonolysis and its synthetic importance.
 8. Delocalized chemical bonding.
 9. Asymmetric synthesis of chiral drugs.
10. Phase transfer catalysis in reduction reaction.
*******

Dr. MGR University APRIL 2015 Question Paper
Subject : PAPER II – ADVANCED ORGANIC CHEMISTRY

[LG 344] Sub. Code: 2905
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER II – ADVANCED ORGANIC CHEMISTRY
Q.P. Code : 262905
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. What do you understand by the term aliphatic nucleophilic substitution reactions?
 Explain the reaction, kinetics, mechanism, stereochemistry and factor affect of SN1
 reactions.
 2. Discuss the reaction, mechanism and synthetic importance of
 a) Grignard reaction
 b) Hoffman reactions
 c) Oppenauer oxidation.
II. Write notes on : (10 x 6 = 60)
 1. Discuss the effect of structure on reactivity with suitable examples.
 2. Write note on asymmetric synthesis.
 3. Write note on E2 elimination reactions.
 4. Write note on electro cyclic reactions.
 5. Discuss the synthetic approach and medical use of any one five member heterocyclic
 ring system.
 6. Discuss the various types of mechanism with suitable examples.
 7. Discuss the chirality and importance of chiral drugs.
 8. Discuss the formation and stability free radicals.
 9. Discuss the orientation and reactivity of monosubstituted benzene.
10. Write note on selective functional group inter-conversions.
******* 

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