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Friday, January 29, 2016

Dr. MGR University 2011 to 2015 Question Papers PAPER IV ADVANCES IN DRUG DELIVERY SYSTEMS

Dr. MGR University  MAY 2011 Question Paper
Subject : PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS

[KY 343] Sub. Code: 2904
M.PHARM. DEGREE EXAMINATION
(Regulations 2010)
Candidates admitted from 2010-2011 onwards
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS
Q.P. Code : 262904
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (6 x 10 = 60)
 1. Discuss in detail about physiochemical properties of drug molecule influencing the
 design and performance of sustained release drug delivery system.
 2. Explain with examples biodegradable and nonbiodegradable polymers used for
 controlled drug delivery systems.
 3. Discuss the principle and procedure for in vitro and in vivo evaluation of controlled
 released drug delivery.
 4. Give an account of approaches and applications of implantable drug delivery systems.
 5. Enumerate the characteristics of drug to be formulated transdermal drug delivery
 systems. Discuss any two methods of formulating transdermal drug delivery systems.
 6. Discuss the design and development of oral controlled release drug administration.
II. Write notes on : (8 x 5 = 40)
 1. Occusert.
 2. Microencapsulation technique.
 3. Permeation enhancers.
 4. Diffusion controlled drug delivery.
 5. Osmotic pressure control.
 6. Granule coated products.
 7. Classification of polymers.
 8. Dissolution test for evaluating oral sustained release drug delivery systems.
*******

Dr. MGR University OCTOBER 2011 Question Paper
Subject : PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS

[KZ 343] Sub. Code: 2904
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS
Q.P. Code : 262904
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
 1. Classify polymers and write the applications of
 polymers in controlled drug delivery systems. 17 40 min. 20
 Discuss in detail about biodegradable and natural polymers.
 2. Explain the principle and techniques of formulating
 nanoparticles. 17 40 min. 20
II. Write notes on :
 1. Osmotic pressure controlled drug delivery systems. 4 10 min. 6
 2. Long acting in insulin preparations. 4 10 min. 6
 3. New trends used in ophthalmic drug delivery systems. 4 10 min. 6
 4. Resealed erythrocytes as targeted drug delivery systems. 4 10 min. 6
 5. Monoclonal antibodies. 4 10 min. 6
 6. Magnetic microspheres. 4 10 min. 6
 7. Microencapsulation by spray drying and spray congealing. 4 10 min. 6
 8. Buccal strips. 4 10 min. 6
 9. Matrix devices controlled drug delivery systems. 4 10 min. 6
10. Factors affecting permeation of transdermal drug delivery systems. 4 10 min. 6
*******

Dr. MGR University  MAY 2012 Question Paper
Subject : PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS

[LA 343] Sub. Code: 2904
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS
Q.P. Code : 262904
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
 1. Discuss in detail about liposomal drug delivery system
 in drug targeting to a specific site. 17 40 min. 20
 2. Describe mucoadhesive drug delivery systems and
 its various methods of preparation and evaluation. 17 40 min. 20
II. Write notes on :
 1. Biodegradable polymers. 4 10 min. 6
 2. Subdermal implants. 4 10 min. 6
 3. Long acting penicillin preparations. 4 10 min. 6
 4. Factors influencing colon targeting drug delivery systems. 4 10 min. 6
 5. Ion exchange controlled drug delivery systems. 4 10 min. 6
 6. Prodrug. 4 10 min. 6
 7. Components in transdermal drug delivery systems. 4 10 min. 6
 8. Give a brief account on nasal absorption and
 various approaches for its enhancement. 4 10 min. 6
 9. Spansules. 4 10 min. 6
10. Explain design and mechanism of occuserts. 4 10 min. 6
*******

Dr. MGR University OCTOBER 2012 Question Paper
Subject : PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS

[LB 343] Sub. Code: 2904
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS
Q.P. Code : 262904
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
 1. What are Buccal drug delivery systems?
 Write a detail note on Merits, Demerits, Structure of Oral mucosa
 and Buccal absorption. 17 40 min. 20
 2. Discuss in detail Rate controlled drug delivery system and
 Explain the invitro and invivo Evaluation of Rate controlled 17 40 min. 20
 drug delivery system.
II. Write Notes on :
 1. Oral controlled drug delivery system. 4 10 min. 6
 2. Applications of Polymers in Controlled drug delivery system. 4 10 min. 6
 3. Long acting contraceptive preparations. 4 10 min. 6
 4. Structure of Skin and Permeation of TDDS. 4 10 min. 6
 5. Coacervation and Phase separation technique. 4 10 min. 6
 6. Applications of Nasal drug delivery system. 4 10 min. 6
 7. Liposomes and Brain targeting. 4 10 min. 6
 8. Insitu Gels. 4 10 min. 6
 9. Ion-exchange resins. 4 10 min. 6
10. Evaluation of TDDS. 4 10 min. 6
*******

Dr. MGR University APRIL 2013 Question Paper
Subject : PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS

[LC 343] Sub. Code: 2904
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS
Q.P. Code : 262904
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. Discuss in detail Physicochemical & Biological factors influencing Design of SRDDS.
 2. Discuss in detail the Formulation approaches and Evaluation of TDDS.
II. Write notes on : (10 x 6 = 60)
 1. Classify Polymers and Write the applications of Polymers in CDDS.
 2. Long acting Insulin preparations.
 3. In-vitro and In-vivo Evaluation of Rate controlled drug delivery systems.
 4. Write a note on Ocular inserts.
 5. Resealed Erythrocytes.
 6. Magnetic Microspheres.
 7. Advantages and Dis-advantages of Mucoadhesive drug delivery system.
 8. Add a note on Buccal drug delivery system.
 9. Oral controlled release drug delivery system.
10. Microencapsulation techniques systems.
*******

Dr. MGR University OCTOBER 2013 Question Paper
Subject : PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS

[LD 343] Sub. Code: 2904
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS
Q.P. Code : 262904
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. Define targeting. Discuss in detail Liposomal Drug Delivery system.
 2. Describe in detail ocular drug delivery system.
II. Write notes on : (10 x 6 = 60)
 1. Differentiate sustained, Controlled and Conventional Drug Delivery System.
 2. Co acervation phase separation.
 3. Non Biodegradable polymers.
 4. Long acting contraceptives
 5. Various approaches for colon targeting.
 6. pH controlled drug delivery system.
 7. Nanoparticles.
 8. Resealed erythrocytes.
 9. Permeation enhancers in Transdermal Delivery.
10. Write note on Pulmonary drug delivery system.
*******

Dr. MGR University APRIL 2014 Question Paper
Subject : PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS

[LE 343] Sub. Code: 2904
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS
Q.P. Code : 262904
Time: Three Hours Maximum: 100 marks
I. Elaborate on : (2 x 20 = 40)
 1. Explain the concepts and design of rate controlled drug delivery system.
 2. Enumerate the characteristics of drug to be formulated as Transdermal Drug Delivery
 System. Explain formulation and evaluation in detail.
II. Write notes on : (10 x 6 = 60)
 1. Detail the physicochemical properties of Sustained Drug Delivery Systems.
 2. Give the principle of Microencapsulation.
 Explain any one technique adopted for bringing about Microencapsulation.
 3. Give an account of Natural Polymers used in Drug Delivery System
 4. Write a note on Liposomal drug delivery.
 5. Add a note on Magnetically responsible microspheres
 6. Write a note on Long acting Pencillin preparations.
 7. Explain Ocular controlled drug delivery in detail.
 8. Write note on Transmucosal permeability and permeation enhancers.
 9. Explain briefly Pulmonary drug delivery system.
10. Describe in detail Gastro intestinal retention of oral drug delivery system.
*******

Dr. MGR University OCTOBER 2014 Question Paper
Subject : PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS

[LF 343] Sub. Code: 2904
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS
Q.P. Code : 262904
Time: Three Hours Maximum: 100 marks
I. Elaborate on : (2 x 20 = 40)
 1. Define Mucoadhesive drug delivery systems and the various methods of preparation
 and evaluation.
 2. Discuss the design and development of controlled release oral drug delivery system.
II. Write notes on : (10 x 6 = 60)
 1. Physiochemical properties of drug influencing design of Sustained release preparations.
 2. Biodegradable polymers.
 3. Implants.
 4. Long acting penicillin preparations.
 5. Evaluation of transdermal drug delivery systems.
 6. Opthlalmic in situ gels.
 7. Liposomes.
 8. Buccal strips.
 9. Feedback regulated drug delivery systems.
10. Nanoparticles.
*******

Dr. MGR University APRIL 2015 Question Paper
Subject : PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS

[LG 343] Sub. Code: 2904
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I – PHARMACEUTICS
PAPER IV – ADVANCES IN DRUG DELIVERY SYSTEMS
Q.P. Code : 262904
Time: Three Hours Maximum: 100 marks
I. Elaborate on : (2 x 20 = 40)
 1. Describe the Formulation approaches used in the development of Transdermal delivery
 systems. Explain the evaluation for the same.
 2. What is mucoadhesive drug delivery system?
 Discuss the concept of Buccal delivery in detail.
 Write a note on pulmonary drug delivery system.
II. Write notes on : (10 x 6 = 60)
 1. Influence of physicochemical properties of drug in the design of sustained drug
 delivery systems.
 2. Natural polymers used in controlled drug delivery system.
 3. Long acting Insulins.
 4. Osmotic pressure controlled oral drug delivery system.
 5. Ophthalmic inserts.
 6. Vesicular carriers.
 7. Magnetic microspheres.
 8. Rate programmed drug delivery system.
 9. Ion exchange controlled delivery system
10. Invivo evaluation of controlled release drug delivery systems.
******* 

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