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Thursday, January 28, 2016

2009 to 2015 Question Papers Dr. MGR University PAPER III MEDICINAL BIOCHEMISTRY

Dr. MGR University SEPTEMBER 2009 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[KV 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(Regulations 2008-2009 )
(Candidates admitted from 2008-2009 onwards)
FIRST YEAR
PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on: (2 x 20 = 40)
 1. a) Define and classify enzymes. Discuss the various factors affectingenzyme activity.
 b) Explain Glycolysis with its energetics.
 2. a) What are ketone bodies. Write in detail about Ketogenesis.
 b) Discuss in detail about radioimmuno assay & enzyme linked immunosorbent assay.
II. Write notes on: (6 x 5 = 30)
 1. Oxidative phosphorylation.
 2. Urea – cycle.
 3. Replication.
 4. Vanden – Berg reaction.
 5. Lipoproteins.
 6. Urine concentration tests.
*******

Dr. MGR University MARCH 2010 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[KW 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(Regulations 2008-2009 )
(Candidates admitted from 2008-2009 onwards)
FIRST YEAR
PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on: (2 x 20 = 40)
 1. a) Explain TCA cycle in detail with its eneryetics.
 b) Discuss the β – oxidation of saturated fatty acids.
 2. a) Write the biosynthesis of pyrimidine nucleotides.
 b) Enumerate the various liver function test and discuss the tests for serum bilirubin
 and urine bilirubin.
II. Write notes on: (6 x 5 = 30)
 1. Transport across cell membranes.
 2. Co enzymes.
 3. GTT.
 4. Various components of electron transport chain.
 5. Protein biosynthesis.
 6. Jaundice.
*******

Dr. MGR University SEPTEMBER 2010 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[KX 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(Regulations 2008-2009 )
(Candidates admitted from 2008-2009 onwards)
FIRST YEAR
PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on: (2 x 20 = 40)
 1. Describe the reaction, regulation and metabolic significance of citric acid cycle.
 2. Discuss in detail about the metabolism of Cholesterol.
II. Write notes on: (6 x 5 = 30)
 1. Cyclic AMP and their biological significance.
 2. Anaerobic dehydrogenases involved in biological oxidation.
 3. Therapeutic and diagnostic applications of Coenzyme A.
 4. Metabolic disorders of Amino acids.
 5. DNA replication.
 6. Kidney Function Tests.
*******

Dr. MGR University MAY 2011 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[KY 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(Regulations 2008-2009 )
(Candidates admitted from 2008-2009 onwards)
FIRST YEAR
PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on: (2 x 20 = 40)
 1. a) Define enzymes.
 Classify them and describe the factors affecting enzyme activity. (14)
 b) What are coenzymes?
 Describe the biochemical role of niacin and pyridoxine. (6)
 2. a) Define lipids and Explain beta oxidation of fatty acids with its energetics. (14)
 b) Atherosclerosis. (6)
II. Write notes on: (6 x 5 = 30)
 1. Explain in detail about ATP and its biological significance.
 2. Write a brief note on metabolic disorders of carbohydrates.
 3. Radio immuno assay.
 4. Hyperbilirubinemia.
 5. Lipoproteins - Types and functions.
 6. HMP Shunt- A brief account.
*******

Dr. MGR University OCTOBER 2011 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[KZ 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
 (Max.) (Max.) (Max.)
 1. a) Reactions of Oxidative Phosphorylation.
 b) Components of respiratory chain. 17 40 min. 20
 c) Chemiosmotic theory.
 2. a) Reactions of TCA.
 b) Energetics of TCA. 17 40 min. 20
 c) Reactions of β Oxidation.
II. Write notes on :
 1. Active transport. 4 10 min. 6
 2. Structure of cholesterol and its functions. 4 10 min. 6
 3. Determination of sodium in serum. 4 10 min. 6
 4. Transamination. 4 10 min. 6
 5. Porphyrias. 4 10 min. 6
 6. Purine catabolism. 4 10 min. 6
 7. Maple syrup urine and alkatonuria. 4 10 min. 6
 8. ELISA. 4 10 min. 6
 9. Vandenburg. 4 10 min. 6
10. Creatinine clearance test. 4 10 min. 6

*******

Dr. MGR University APRIL 2012 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[LA 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
 (Max.) (Max.) (Max.)
 1. Write a detailed note on the Urea cycle with reactions.
 Mention its major metabolic disorders. 17 40 min. 20
 2. Explain the semi conservative replication of a double
 stranded DNA molecule. Add a note on its repair 17 40 min. 20
 mechanism.
II. Write notes on :
 1. Explain the Van den Bergh reaction. 4 10 min. 6
 2. Discuss the biological significance of cyclic – adenosine
 monophosphate (c-AMP). 4 10 min. 6
 3. Write a note on Atherosclerosis. 4 10 min. 6
 4. Explain the mechanism of Transamination. 4 10 min. 6
 5. Explain the biochemical organisation of a cell. 4 10 min. 6
 6. Enumerate the IUB classification of enzymes with example. 4 10 min. 6
 7. Explain the Galactose tolerance test. 4 10 min. 6
 8. What are the various types of Porphyrias. 4 10 min. 6
 9. Write a note on Urine analysis. 4 10 min. 6
10. Write a note on Urea clearance. 4 10 min. 6
*******

Dr. MGR University OCTOBER 2012 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[LB 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
 (Max.) (Max.) (Max.)
 1. Explain the Hexose Monophosphate (HMP) Shunt.
 Add a note on its significance. 17 40 min. 20
 2. Explain the various functions of liver.
 Elaborate any two liver function tests. 17 40 min. 20
II. Write notes on:
 1. Write a note on Creatinine clearance test. 4 10 min. 6
 2. Discuss Radio Immuno Assay. 4 10 min. 6
 3. Discuss Adenosine triphosphate (ATP) as an energy rich
 compound. 4 10 min. 6
 4. Discuss the diagnostic applications of iso-enzymes. 4 10 min. 6
 5. Write a note on Diabetes mellitus. 4 10 min. 6
 6. Write a note on Hypercholesterolemia. 4 10 min. 6
 7. Explain the collection of blood samples in a clinical chemistry
 laboratory. 4 10 min. 6
 8. Enumerate the factors affecting enzyme activity. 4 10 min. 6
 9. Explain Oxidative phosphorylation. 4 10 min. 6
10. What are the features of Genetic code. 4 10 min. 6
*******

Dr. MGR University APRIL 2013 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[LC 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
 PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 100 marks
 Answer All questions
I. Elaborate on: (2 x 20 = 40)
 1. Write a detailed note on the Urea cycle with reactions.
 Mention its major metabolic disorders.
 2. Explain the semiconservative replication of a double stranded DNA molecule.
 Add a note on its repair mechanism.
II. Write notes on: (10 x 6 = 60)
 1. Explain the Van den Bergh reaction.
 2. Discuss the biological significance of cyclic – adenosine monophosphate (c-AMP).
 3. Write a note on Atherosclerosis.
 4. Explain the mechanism of Transamination.
 5. Explain the biochemical organisation of a cell.
 6. Enumerate the IUB classification of enzymes with example.
 7. Explain the Galactose tolerance test.
 8. What are the various types of Porphyrias.
 9. Write a note on Urine analysis.
10. Write a note on Urea clearance.
*******

Dr. MGR University APRIL 2014 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[LE 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
FIRST YEAR
PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 70 marks
 Answer All questions
I. Elaborate on: (2 x 20 = 40)
 1. a) Describe the reactions and significance of HMP shunt.
 b) Explain about the β-oxidation of fatty acids.
 2. Explain the semi conservative replication of a double stranded DNA molecule.
 Add a note on its repair mechanism.
II. Write notes on: (10 x 3 = 30)
 1. What are zymogens? Give examples.
 2. Write a brief note on chemiosmotic theory.
 3. State the central dogma of molecular biology.
 4. What are isoenzymes? Give its applications.
 5. What is renal threshold? Give the renal threshold value for glucose.
 6. Briefly explain the structure of plasma membrane.
 7. Purine catabolism.
 8. Define hyperbilirubinemia. Name the tests for bilirubin in urine.
 9. Discuss about the key regulator enzymes in glycolysis.
10. Explain about the biological significance of cAMP.
*******

Dr. MGR University OCTOBER 2014 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[LF 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(2009-2010 Regulation)
FIRST YEAR
PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 70 marks
 Answer All questions
I. Elaborate on: (4 x 10 = 40)
 1. Explain in detail about the reactions and energetic of beta oxidation of fatty acid.
 2. Describe about the biosynthesis of porphyrin.
 3. Discuss in detail about the various test to access kidney function Test.
 4. Explain the factors influencing enzyme activity.
II. Write notes on: (6 x 5 = 30)
 1. Mechanism of enzyme action.
 2. Glycogen storage diseases.
 3. Biochemical functions of insulin.
 4. Genetic code and its features.
 5. Determination of sodium in serum.
 6. What is dehydration? Write the different types of dehydration.
*******

Dr. MGR University APRIL 2015 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[LG 803] Sub. Code: 3803
DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(2009-2010 Regulation)
FIRST YEAR
PAPER III – MEDICINAL BIOCHEMISTRY
Q.P. Code: 383803
Time: Three Hours Maximum: 70 marks
 Answer All questions
I. Elaborate on: (4 x 10 = 40)
 1. Explain in detail and significance of Glycolysis.
 2. Describe about the degradation and biosynthesis of Cholesterol.
 3. Explain in detail about the components and reactions of ETC.
 4. Describe in detail about the urea cycle and its disorder.
II. Write notes on: (6 x 5 = 30)
 1. What are inhibitors? Classify them with suitable example.
 2. Uncouplers.
 3. Endocrine disorders of Thyroid gland and adrenal glands.
 4. Urea Clearance Test.
 5. What is Mutation? Write the different types of Mutation.
 6. What is blood buffer? Write the different types of blood buffer system.
*******

Dr. MGR University OCTOBER 2015 Question Paper
Subject : PAPER III  MEDICINAL BIOCHEMISTRY

[LH 803] Sub. Code: 3803
PHARM. D DEGREE EXAMINATION
(2009-2010 Regulation)
FIRST YEAR
PAPER III – MEDICINAL BIO-CHEMISTRY
Q.P. Code : 383803
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on : (4 x 10 = 40)
 1. Describe in detail about Radio Immuno Assay and ELISA.
 2. Discuss the Clinical importance of Enzyme.
 3. Discuss in detail about the various test to access Liver Function Test.
 4. Describe in detail about the reaction of TCA cycle.
II. Write notes on : (6 x 5 = 30)
 1. Porphyrias.
 2. Biological Significance of cyclic AMP.
 3. Write any one metabolism of Amino Acid.
 4. Write a note on Co-enzyme and its functions.
 5. Glucogenolysis.
 6. ATP-ADP Cycle.
******* 

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