Saturday, July 11, 2015

WBUT B.Sc Microbiology Computational Biology & Bio-Informatics Question Paper of 2013

University: West Bengal University
Course: B.sc Microbiology
Subject :  Computational Biology & Bio-Informatics

Year of  Question Paper : 2013

CS/B.Sc.(H)/BT/Gen/Micro-Bio/Mol-Bio/SEM-4/CBB-402/2013

2013

COMPUTATIONAL BIOLOGY & BIOINFORMATICS

Time Allotted : 3 Hours Full Marks : 70

The figures in the margin indicate full marks.

Candidates are required to give their answers in their own words

as far as practicable.

GROUP – A

( Multiple Choice Type Questions )

1. Choose the correct alternatives for any ten of the following : [Marks 10 × 1 = 10]

i) Which of these is not a protein sequence database ?

a) PIR b) GenBank

c) PDB d) Swiss-Prot.

ii) BCA stands for

a) Bacteria Artifice Chromosome

b) Bacterial Artifice Chromosome

c) Bacterial Artificial Chromosome

d) Bacterial Artificial Chromatid.

iii) Which step is omitted in whole genome sequencing ?

a) Random shqedding of genome

b) Making phage library

c) Computational analysis

d) None of these.

iv) Which of the following is not primary nucleotide

sequence database ?

a) DDBJ b) OWL

c) GEN BANK d) EMBL.

v) URL for NCBI is

a) www.ncbi.nlm.nih.gov b) www.ncbi.nih.nlm.gov

c) www.ncbi.gov d) www.ncbi.nlm.gov.

vi) Clastal W

a) multiple sequence alignment tool

b) protein secondary structure predicting tool

c) data retrieving tool

d) nucleic acid sequence analysis tool.

vii) Which is data retiring tool ?

a) KEGG b) EMBL

c) ENTERZ d) PHD.

viii) BLAST & FASTA are used for

a) global similarity

b) end free space alignment

c) local similarity

d) gap penalty.

ix) Information of all known nucleotide & protein sequel are

available on

a) NCBI gene bank b) DDBJ

c) EMBL d) all of these.

x) What is the primary goals of databases ?

a) Minimizing data redundancy

b) Achieving data independence

c) Both (a) and (b)

d) None of these.

xi) Phylogenetic relationship can be shown by

a) Dendogram b) Data search tool

c) Data retrieving d) Gene bank.

xii) Proteomics research can be categorized as

a) structural proteomics & functional proteomics

b) structural functional & comparative functional

c) functional & comparative proteomics

d) none of these.


GROUP – B

( Short Answer Type Questions )

Answer any three of the following. [Marks 3 × 5 = 15]

2. Define WWW, HTTP, HTML, URL.

3. What is substitution matrix ? Write down the difference

between PAM & BLOSUM matrix. [Marks 2 + 3]

4. What is sequence alignment ? Write about E value & Z score. [Marks 2 + 3]

5. Write down the difference between FASTA & BLAST. [Marks 2 + 3]

6. Write about data retrieval tool. What is sequin & bankit ? [Marks 2 + 3]

GROUP – C

( Long Answer Type Questions )

Answer any three of the following. [Marks 3 × 15 = 45]

7. a) What is Secondary Database ? Name two Secondary

Databases.

b) What is the difference between Accession Number and

Gi Number ?

c) What are the basis of database searching in

bioinformatics ?

d) What do you mean by BankIT ? [Marks 1 + 2 + 4 + 5 + 3]

8. a) Compare the features between Primary, Secondary and

Tertiary database.

b) What is PFAM and BLOCKS ?

c) Write down the differences between Flat File and

Hierarchical files.

d) Why Biological Database are important ? [Marks 5 + 3 + 4 + 3]

9. What is Dynamic Programming ? What are the general steps

of it ? Name two database searching tools. Fill the matrix for

DP and align the following sequences :

GAATTCAGTTA (sequence#1) (Upto Matrix fill step only)

GGATCGA (sequence#2) [Marks 2 + 1 + 2 + 7 + 3]

10. What is substitution matrix ? In "PAM 250" the 250 stands

for what ? Write down the difference of PAM 250 and

BIOSSM 62 matrix. What is humming and levenstein

distance ? Write down one name of two small molecule

database. What is Pubmed ? What is the name of the

database where you get the inheritable disease of human ?

What is word size ? Comment on sensitivity and selectivity ?

[Marks 1 + 1 + 3 + 4 + 1 + 1 + 1 + 1 + 2]

11. State the difference between homology and similarity ? Write

down 6 emerging fields in bioinformatics. You have given a

sequence of African elephant and Indian elephant how would

you draw the phylogenetic relation between them ? What

would you expect the result. What is relative mutability ? [Marks 3 + 3 + 4 + 2 + 3]

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